Relative importance of systemic determinants of retinal arteriolar and venular caliber
Relative importance of systemic determinants of retinal arteriolar and venular caliber
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DOI：
10.1001/archopht.126.10.1404
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发表时间：
2008-10-01
影响因子：
--
通讯作者：
Wong, Tien Y.
中科院分区：
文献类型：
--
作者：
Liew, Gerald;Sharrett, A. Richey;Wong, Tien Y.
目的：探讨系统性心血管因素对男性、女性、白人和非裔美国人视网膜小动脉和静脉直径的相对影响。方法：在社区动脉粥样硬化风险研究中，从8794名参与者的数字化视网膜照片中测量视网膜小动脉口径（视网膜中央小动脉当量）和静脉口径（视网膜中央小静脉当量）。结果：Harrower视网膜中央动脉当量的主要系统决定因素依次为：较高的当前平均动脉血压、较低的血清白蛋白水平、当前饮酒和较高的体重指数（计算方法为体重（公斤）除以身高（米）的平方）。视网膜中央静脉当量变宽的主要系统性决定因素是当前吸烟和当前平均动脉血压升高，其次是白细胞计数、体重指数和血浆低密度脂蛋白胆固醇水平升高。这些关联在白人和非裔美国人以及男性和女性中普遍相似。结论：视网膜小动脉口径变窄的主要系统性决定因素是血压升高，而视网膜小动脉口径变宽的主要系统性决定因素是吸烟、血压升高、全身性炎症和肥胖。这些数据对影响小动脉和静脉特征的系统过程提供了进一步的见解，并可能有助于解释观察到的视网膜血管口径与临床心血管疾病风险的关联。
Objective: To examine the relative contributions of systemic cardiovascular factors to retinal arteriolar and venular caliber in men and women and in whites and African Americans.Methods: In the Atherosclerosis Risk in Communities study, retinal arteriolar caliber (central retinal arteriolar equivalent), and venular caliber (central retinal venular equivalent) were Measured from digitized retinal photographs of 8794 participants.Results: The main systemic determinants of Harrower central retinal arteriolar equivalent were, in order relative decreasing contribution, higher current mean arterial blood pressure, lower serum albumin level, current alcohol consumption, and higher body mass index (calculated as weight in kilograms divided by height in meters squared). The main systemic determinants of wider central retinal venular equivalent were current cigarette smoking and higher current mean arterial blood pressure, followed by higher white blood cell count, body mass index, and plasma low-density lipoprotein cholesterol levels. These associations were generally similar in whites and African Americans and in men and women.Conclusions: The major systemic determinant of narrower retinal arteriolar caliber is higher blood pressure, while those of wider retinal venular caliber are cigarette smoking, higher blood pressure, systemic inflammation, and obesity. These data offer further insights into the systemic processes influencing arteriolar and venular characteristics and may help explain the observed associations of retinal vascular caliber and the risk of clinical cardiovascular disease.