The role of infection in restenosis and atherosclerosis: Focus on cytomegalovirus
The role of infection in restenosis and atherosclerosis: Focus on cytomegalovirus
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DOI：
10.1016/s0140-6736(96)98005-8
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发表时间：
1996-11-01
期刊：
影响因子：
168.9
通讯作者：
Finkel, T
中科院分区：
文献类型：
--
作者：
Epstein, SE;Speir, E;Finkel, T
许多动脉硬化患者目前缺乏确定的危险因素，冠状动脉血管成形术后再狭窄的危险因素也没有一致的确定。因此，确定导致动脉粥样硬化的其他因素对于制定进一步减少动脉粥样硬化和再狭窄发生率的治疗策略是必要的。本文的目的是考虑的证据，传染性病原体诱导血管壁细胞的改变，这两种疾病过程的易感性。我们将主要关注疱疹病毒，特别是巨细胞病毒的潜在作用，因为在过去的23年里，几个实验室的工作已经提供了大量的数据，指出这种病毒在动脉粥样硬化和最近的再狭窄中的因果作用。
Many patients with arteriosclerosis lack currently identified risk factors and no risk factors have been consistently identified for restenosis after coronary angioplasty. Therefore, the identification of additional factors which contribute to atherogenesis is necessary to develop therapeutic strategies that can further reduce the incidence of atherosclerosis and restenosis. The purpose of this paper is to consider the evidence that infectious agents induce alterations in cells of the vascular wall that predipose to both of these disease processes. We will focus mainly on the potential role of herpesviruses, and in particular cytomegalovirus, since work in several laboratories over the past 23 years has contributed a substantial body of data pointing to a causal role for this virus in atherosclerosis and, more recently, in restenosis.