Metabolic activation of mutagenic tryptophan pyrolysis products (Trp-P-1 and Trp-P-2) by a purified cytochrome P-450-dependent monooxygenase system.
Metabolic activation of mutagenic tryptophan pyrolysis products (Trp-P-1 and Trp-P-2) by a purified cytochrome P-450-dependent monooxygenase system.
复制标题
通过纯化的细胞色素 P-450 依赖性单加氧酶系统代谢激活诱变色氨酸热解产物（Trp-P-1 和 Trp-P-2）。
DOI：
10.1016/0304-3835(80)90017-8
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发表时间：
1980
期刊：
影响因子：
9.7
通讯作者：
M. Nagao
中科院分区：
文献类型：
--
作者：
Kenji Ishii;M. Ando;Tetsuya Kamataki;R. Kato;M. Nagao
色氨酸热解产物Trp-P-1和Trp-P-2被从大鼠肝微粒体中纯化的细胞色素P-450激活，产生对鼠伤寒沙门氏菌具有诱变性的代谢物。在测试的四种纯化细胞色素P-450制剂中，PCBP-448和MCP-448显示出高活性，而PCBP-450和PBP-450活性较低。回复体的数量与在所用条件下添加的细胞色素PCBP-448的量成正比。
Tryptophan pyrolysis products, Trp-P-1 and Trp-P-2, were activated to metabolites mutagenic toSalmonella typhimuriumby cytochromeP-450 purified from rat liver microsomes. Of the four purified cytochromeP-450 preparations tested, PCBP-448 and MCP-448 showed high activity, while PCBP-450 and PBP-450 were less active. The number of revertants was proportional to the amount of cytochrome PCBP-448 added under the conditions used.