POPULATION CODING OF SACCADIC EYE-MOVEMENTS BY NEURONS IN THE SUPERIOR COLLICULUS
POPULATION CODING OF SACCADIC EYE-MOVEMENTS BY NEURONS IN THE SUPERIOR COLLICULUS
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DOI：
10.1038/332357a0
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发表时间：
1988-03-24
期刊：
影响因子：
64.8
通讯作者：
SPARKS, DL
中科院分区：
文献类型：
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作者：
LEE, CK;ROHRER, WH;SPARKS, DL
上级丘的深层参与扫视（高速）眼球运动的启动和执行1。在每次扫视之前，大量粗调的丘神经元是活跃的。从人群活动中提取精确控制扫视方向和幅度的信号的机制尚不清楚。据推测2 - 6，扫视的确切轨迹是由整个群体的活动决定的，并且在神经处理的后续阶段，信息不仅仅是从群体中最活跃的细胞中提取的。扫视的轨迹可以基于由活跃神经元群体4的每个成员提供的运动趋势的矢量总和，或者由活跃群体2中每个神经元的矢量贡献的加权平均来确定。在这里，我们提出了实验的结果，其中一个小的子集的活性人口可逆地与利多卡因失活。这些结果与后一种群体平均假设的预测是一致的，并且支持这样的一般想法，即扫视眼球运动的方向、幅度和速度是基于在扫视眼球运动之前活跃的整个细胞群体的响应。
The deeper layers of the superior colliculus are involved in the initiation and execution of saccadic (high velocity) eye movements1. A large population of coarsely tuned collicular neurons is active before each saccade. The mechanisms by which the signals that precisely control the direction and amplitude of a saccade are extracted from the activity of the population are unknown. It has been assumed2–6that the exact trajectory of a saccade is determined by the activity of the entire population and that information is not extracted from only the most active cells in the population at a subsequent stage of neural processing. The trajectory of a saccade could be based on vector summation of the movement tendencies provided by each member of the population of active neurons4or be determined by a weighted average of the vector contributions of each neuron in the active population2. Here we present the results of experiments in which a small subset of the active population was reversibly deactivated with lidocaine. These results are consistent with the predictions of the latter population-averaging hypothesis and support the general idea that the direction, amplitude and velocity of saccadic eye movements are based on the responses of the entire population of cells active before a saccadic eye movement.