Lung Function Impairment and Metabolic Syndrome The Critical Role of Abdominal Obesity
Lung Function Impairment and Metabolic Syndrome The Critical Role of Abdominal Obesity
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DOI：
10.1164/rccm.200807-1195oc
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发表时间：
2009-03-15
影响因子：
24.7
通讯作者：
Zureik, Mahmoud
中科院分区：
文献类型：
--
作者：
Leone, Nathalie;Courbon, Dominique;Zureik, Mahmoud
原理：心血管发病率和死亡率的风险增加与肺功能损害和代谢综合征有关。肺功能和代谢综合征之间的关系的数据是sparsely.Objectives：调查肺功能损害的风险根据metabolic syndrome traits.Methods：这项横断面人群为基础的研究包括121，965名男性和女性在巴黎调查研究与临床中心在1999年和2006年之间。以正常值下限定义肺功能损害（FEV 1或FVC <正常值下限）。代谢综合征进行了评估，根据美国心脏协会/国家心脏，肺和血液研究所statement.Measurements和主要结果：我们使用了logistic回归模型和主成分分析，以探讨肺功能损害和代谢综合征的具体组成部分之间的差异关联。肺功能损害与代谢综合征有关（患病率= 15.0%）独立于年龄、性别、吸烟状况、饮酒、教育水平、体重指数、闲暇时间体力活动和心血管疾病史（FEV 1和FVC的比值比[OR] [95%置信区间]分别为1.28 [1.20-1.37]和1.41 [1.31-1.51]）。从因子分析中确定了三个因子：“血脂”（低高密度脂蛋白胆固醇、高甘油三酯）、“血糖-血压”（空腹血糖高、高血压）和“腹部肥胖”（腰围大）。所有因素均与肺功能呈负相关，但腹部肥胖是肺功能损害的最强预测因子（FEV 1和FVC的OR分别为1.94 [1.80-2.09]和2.11 [1.95-2.29]）。女性和男性也获得了类似的结果。结论：我们发现男性和女性的肺功能损害与代谢综合征之间存在独立的正相关关系，主要是由于腹部肥胖。需要进一步的研究来阐明潜在的机制。
Rationale: Increased risk for cardiovascular morbidity and mortality has been related to both lung function impairment and metabolic syndrome. Data on the relationship between lung function and metabolic syndrome are sparse.Objectives: To investigate risk for lung function impairment according to metabolic syndrome traits.Methods: This cross-sectional population-based study included 121,965 men and women examined at the Paris Investigations Preventives et Cliniques Center between 1999 and 2006. The lower limit of normal was used to define lung function impairment (FEV1 or FVC < lower limit of normal). Metabolic syndrome was assessed according to the American Heart Association/National Heart, Lung, and Blood Institute statement.Measurements and Main Results: We used a logistic regression model and principal component analysis to investigate the differential associations between lung function impairment and specific components of metabolic syndrome. Lung function impairment was associated with metabolic syndrome (prevalence = 15.0%) independently of age, sex, smoking status, alcohol consumption, educational level, body mass index, leisure-time physical activity, and cardiovascular disease history (odds ratio [OR] [95% confidence interval], 1.28 [1.20-1.37] and OR, 1.41 [1.31-1.51] for FEV1 and FVC, respectively). Three factors were identified from factor analysis: "lipids" (low high-density lipoprotein cholesterol, high triglycerides), "glucose-blood pressure" (high fasting glycemia, high blood pressure), and "abdominal obesity" (large waist circumference). All factors were inversely related to lung function, but abdominal obesity was the strongest predictor of lung function impairment (OR, 1.94 [1.80-2.09] and OR, 2.11 [1.95-2.29], for FEV1 and FVC, respectively). Similar results were obtained for women and men.Conclusions: We found a positive independent relationship between lung function impairment and metabolic syndrome in both sexes, predominantly due to abdominal obesity. Further studies are required to clarify the underlying mechanisms.