Hereditary gynecologic cancers: differential diagnosis, surveillance, management and surgical prophylaxis
Hereditary gynecologic cancers: differential diagnosis, surveillance, management and surgical prophylaxis
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DOI：
10.1007/s10689-007-9144-x
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发表时间：
2008-03-01
期刊：
影响因子：
2.2
通讯作者：
Lu, Karen H.
中科院分区：
文献类型：
--
作者：
Lu, Karen H.
涉及妇科癌症的主要癌症易感综合征包括乳腺癌卵巢癌综合征和林奇综合征/遗传性非息肉病结直肠癌综合征。对于子宫癌，大约 5% 的病例可能是由于遗传原因造成的，对于卵巢癌，大约 10% 是由于遗传原因造成的。妇科肿瘤学家在识别可能患有这些综合征的卵巢癌或子宫内膜癌女性方面发挥着重要作用。相关癌症的个人史和家族史有助于识别。对于那些没有癌症但被发现患有遗传性癌症综合症的女性来说，有效的癌症预防和早期发现咨询至关重要。
The main cancer susceptibility syndromes that involve gynecologic cancers include Breast-Ovarian Cancer Syndrome and Lynch Syndrome/Hereditary Non-polyposis Colorectal Cancer Syndrome. For uterine cancer, approximately 5% of all cases are likely due to a hereditary cause and for ovarian cancer, approximately 10% are due to an inherited cause. Gynecologic oncologists play an important role in identifying women with ovarian or endometrial cancer who may have these syndromes. Personal and family history of relevant cancers assists with identification. For those women without cancer who are found to have a hereditary cancer syndrome, effective counseling in the prevention and early detection of cancers is crucial.