Gelatin "shots" as a new method for alcohol administration in a laboratory setting
Gelatin "shots" as a new method for alcohol administration in a laboratory setting
复制标题
DOI：
10.1111/j.1530-0277.2006.00064.x
复制
发表时间：
2006-03-01
影响因子：
3.2
通讯作者：
Petrakis, I
中科院分区：
文献类型：
--
作者：
Ralevski, E;Gueorguieva, R;Petrakis, I
背景资料：这个实验的目的是比较明胶“镜头”-一个新的程序，管理酒精在实验室设置-酒精饮料的方法。我们继续测试是否这两种方法是可比的酒精吸收，代谢，对情绪的影响，以及是否明胶“镜头”更好地伪装酒精饮料在一个盲目的，安慰剂comparation.Methods：健康志愿者参加了一个两阶段的试验。在第一阶段，他们完成了为期2天的测试，在此期间，评估了在饮料（第一天）或明胶“镜头”（交替一天）中提供的酒精对血液和呼吸测醉器浓度和情绪的影响。在第二阶段，参与者完成了2天的测试，并被要求确定样本中是否含有酒精或安慰剂。酒精和安慰剂的介绍和饮料或明胶的介绍“镜头”是随机的。结果：在第一阶段有一个显着的时间由条件的相互作用，在血液中的酒精浓度。在服用酒精两个半小时后，那些服用明胶“注射剂”的人血液中酒精浓度略低，但具有统计学意义。有一个显着的时间效应，酒精浓度，但没有条件或条件的时间相互作用。两种方法在任何主观情绪测量上都没有差异。在第二阶段的研究有差异的能力，以区分酒精安慰剂之间的两个条件，有显着更多的参与者在明胶的错误“镜头”比在饮料condition.Conclusions：我们的研究结果表明，明胶“镜头”是一种有效的方法，提供酒精给人类在实验室环境。在安慰剂对照设计中，这种方法可能上级酒精饮料混合物，因为明胶“丸”比饮料更好地掩盖酒精，并且更容易给药。
Background: This experiment was designed to compare gelatin "shots"-a new procedure for administering alcohol in a laboratory setting-to the alcohol beverage method. We proceeded to test whether the two methods were comparable in terms of alcohol absorption, metabolism, and effects on mood and whether gelatin "shots" were better than the beverage in disguising alcohol in a blind, placebo comparison.Methods: Healthy volunteers participated in a two-phase trial. In the first phase they completed 2 days of testing during which the effects of alcohol-delivered in beverage (I day) or gelatin "shots" (alternative day)-on blood and breathalyzer concentrations and mood were assessed. In the second phase participants completed 2 days of testing and were asked to identify if samples contained alcohol or placebo. The presentation of alcohol and placebo and the presentation of beverage or gelatin "shots" were random.Results: In the first phase there was a significant time-by-condition interaction in the blood alcohol concentration. Two-and-a-half hours after the alcohol was administered, those given gelatin "shots" had slightly lower but statistically significant blood alcohol concentrations. There was a significant time effect for breathalyzer alcohol levels but no condition or condition-by-time interaction. There were no differences between the two methods on any of the subjective mood measures. In the second phase of the study there were differences in the ability to differentiate alcohol from placebo between the two conditions with significantly more participants making errors in the gelatin "shots" than in the beverage condition.Conclusions: Our findings indicate that gelatin "shots" are an effective method for delivering alcohol to humans in a laboratory setting. This method may be superior to the alcohol beverage mixture in a placebo-con trolled design because gelatin "shots" mask the alcohol much better than a beverage and are easier to administer.