Revisit 18F-fluorodeoxyglucose oncology positron emission tomography: "systems molecular imaging" of glucose metabolism.
Revisit 18F-fluorodeoxyglucose oncology positron emission tomography: "systems molecular imaging" of glucose metabolism.
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DOI：
10.18632/oncotarget.16647
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发表时间：
2017-06-27
期刊：
影响因子：
--
通讯作者：
Li XF
中科院分区：
文献类型：
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作者：
Shen B;Huang T;Sun Y;Jin Z;Li XF
18F-氟脱氧葡萄糖 (18F-FDG) 正电子发射断层扫描已成为多种癌症检测、分期和治疗的重要工具。 18F-FDG 的肿瘤学应用基于以下认识：葡萄糖需求和利用的增加是癌症的基本特征。巴斯德效应、瓦尔堡效应和反瓦尔堡效应已被用来解释癌症中的葡萄糖代谢。据报道，癌症中 18F-FDG 的积累依赖于微环境，18F-FDG 在增殖不良和缺氧的癌细胞中大量积累，但在灌注良好（和增殖）的癌细胞中积累很少。癌症是一个异质且复杂的包含多种成分的“器官”，因此，需要从系统生物学的角度来研究癌症，为了更好地理解癌症的系统生物学，我们提出了“系统分子成像”的概念。本文回顾了 18F-FDG 摄取机制、其肿瘤学应用以及 18F-FDG PET 在“系统分子成像”中的作用。
18F-fluorodeoxyglucose (18F-FDG) positron emission tomography has become an important tool for detection, staging and management of many types of cancer. Oncology application of 18F-FDG bases on the knowledge that increase in glucose demand and utilization is a fundamental features of cancer. Pasteur effect, Warburg effect and reverse Warburg effect have been used to explain glucose metabolism in cancer. 18F-FDG accumulation in cancer is reportedly microenvironment-dependent, 18F-FDG avidly accumulates in poorly proliferating and hypoxic cancer cells, but low in well perfused (and proliferating) cancer cells. Cancer is a heterogeneous and complex “organ” containing multiple components, therefore, cancer needs to be investigated from systems biology point of view, we proposed the concept of “systems molecular imaging” for much better understanding systems biology of cancer. This article revisits 18F-FDG uptake mechanisms, its oncology applications and the role of 18F-FDG PET for “systems molecular imaging”.