[Antimotion sickness effects of ginsenosides combined with dexamethasone in rats].
[Antimotion sickness effects of ginsenosides combined with dexamethasone in rats].
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DOI：
10.3736/jcim201090410
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发表时间：
2010-04-01
期刊：
影响因子：
--
通讯作者：
Li, Min
中科院分区：
文献类型：
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作者：
Jia, Lin;Wang, Wan-yin;Li, Min
目的：探讨人参皂苷联合地塞米松对大鼠的抗晕动病作用。方法：50只SD大鼠随机分为生理盐水组、东莨菪碱组、人参皂苷组、地塞米松组和人参皂苷加地塞米松组。每组10只。各组大鼠分别饲喂相应成分，然后进行异常加速处理1小时。观察运动病指数、高岭土消耗水平和自主活动的过程和时间。结果：人参皂苷加地塞米松处理组加速暴露大鼠的晕动病指数和高岭土消耗水平显著低于生理盐水处理组。人参皂苷加地塞米松处理组加速暴露大鼠自发活动的时间和过程明显高于生理盐水处理组。人参皂苷加地塞米松处理组加速暴露大鼠的体重增加水平显著高于地塞米松处理组。结论：人参皂苷联合地塞米松可显著提高大鼠对加速的耐受性，并可减轻甲泼尼龙的副作用，如体重减轻。
OBJECTIVE: To investigate the antimotion sickness effects of ginsenosides combined with dexamethasone in rats.METHODS: Fifty SD rats were randomly divided into 5 groups: normal saline, scopolamine-treated, ginsenosides-treated, dexamethasone-treated and ginsenosides plus dexamethasone-treated groups. There were 10 rats in each group. The rats in each group were fed with corresponding ingredients respectively, and then the rats were exposed to abnormal acceleration for one hour. The motion sickness index, the level of kaolin consumption and the course and time of spontaneous activity were observed.RESULTS: The motion sickness index and the level of kaolin consumption of acceleration-exposed rats in ginsenosides plus dexamethasone-treated group were significantly lower than those in normal saline group. And the course and time of spontaneous activity of acceleration-exposed rats in ginsenosides plus dexamethasone-treated group were significantly higher than those in normal saline group. The level of body weight increment of acceleration-exposed rats in ginsenosides plus dexamethasone-treated group was significantly higher than that in dexamethasone-treated group.CONCLUSION: Ginsenosides combined with dexamethasone can significantly increase tolerance to acceleration of rats, and the drug combination can decrease side effects of methylprednisolone, such as body weight loss.