Cerebellar parcellation in schizophrenia and bipolar disorder
Cerebellar parcellation in schizophrenia and bipolar disorder
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DOI：
10.1111/acps.13087
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发表时间：
2019-11-01
影响因子：
6.7
通讯作者：
Houenou, J.
中科院分区：
文献类型：
--
作者：
Laidi, C.;Hajek, T.;Houenou, J.
目的小脑参与认知加工和情绪控制。小脑的改变可以解释精神分裂症谱系障碍(SZ)和双相情感障碍(BD)的症状。此外，文献表明锂可能会影响小脑的解剖结构。我们的目的是研究SZ和BD的小脑解剖，并探讨锂的影响。方法对来自全球7个中心的受试者进行3T磁共振成像。我们包括182名SZ患者、144名BD患者和322名对照组。我们使用CERES管道自动分割了小脑。所有产出都进行了目视检查。结果SZ患者小脑整体灰质体积较对照组缩小，主要位于小脑认知部分(CRU II和小叶VIIB)。这种下降出现在新近发病的SZ患者亚组中。我们没有发现BD患者的小脑有任何改变。然而，与未接受锂治疗的患者相比，接受锂治疗的患者的小脑前部更大。结论我们的多中心研究支持SZ和BD小脑改变的独特模式。
Objective The cerebellum is involved in cognitive processing and emotion control. Cerebellar alterations could explain symptoms of schizophrenia spectrum disorder (SZ) and bipolar disorder (BD). In addition, literature suggests that lithium might influence cerebellar anatomy. Our aim was to study cerebellar anatomy in SZ and BD, and investigate the effect of lithium. Methods Participants from 7 centers worldwide underwent a 3T MRI. We included 182 patients with SZ, 144 patients with BD, and 322 controls. We automatically segmented the cerebellum using the CERES pipeline. All outputs were visually inspected. Results Patients with SZ showed a smaller global cerebellar gray matter volume compared to controls, with most of the changes located to the cognitive part of the cerebellum (Crus II and lobule VIIb). This decrease was present in the subgroup of patients with recent-onset SZ. We did not find any alterations in the cerebellum in patients with BD. However, patients medicated with lithium had a larger size of the anterior cerebellum, compared to patients not treated with lithium. Conclusion Our multicenter study supports a distinct pattern of cerebellar alterations in SZ and BD.