Identification of two new single‐nucleotide polymorphisms in FUT3 associated with the Lewis‐null phenotype
Identification of two new single‐nucleotide polymorphisms in FUT3 associated with the Lewis‐null phenotype
复制标题
鉴定 FUT3 中与 Lewis 无效表型相关的两个新单核苷酸多态性
作者：
L. Cooling;Yuan Gu
BMT后的嵌合现象已被各种遗传标记、红细胞抗原以及较少出现的免疫球蛋白同种异体所证实。与短串联重复序列（STRs）相比，这些标记的敏感性较低，为分析人类多态性提供了有力的工具。STR分析在同种异体骨髓移植患者中的应用已被用于检测移植后早期和晚期的混合或完全嵌合、复发性白血病和骨髓内源性再生。它可以在移植后的一段时间内检测出少量的DNA群体，具有足够的灵敏度，而传统的免疫血液学评估由于需要输入红细胞而受到限制。1
Chimerism after BMT has been documented by various genetic markers, RBC antigens, and, less frequently, by immunoglobulin allotypes. These markers are less sensitive than short tandem repeats (STRs), which provides a powerful tool for analysis of human polymorphisms. Application of STR analysis in patients undergoing allogeneic BMT has been used to detect mixed or complete chimerism, recurrent leukemia, and endogenous repopulation of marrow in early and late phases after transplant. It can detect minor populations of DNA in the period after transplant with adequate sensitivity, whereas traditional immunohematologic evaluation is limited because of the necessity of transfusing RBCs. 1