Effects of wild ginseng (Panax ginseng C.A!Meyer) leaves on lipid peroxidation levels and antioxidant enzyme activities in streptozotocin diabetic rats
Effects of wild ginseng (Panax ginseng C.A!Meyer) leaves on lipid peroxidation levels and antioxidant enzyme activities in streptozotocin diabetic rats
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DOI：
10.1016/j.jep.2004.12.030
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发表时间：
2005-04-26
影响因子：
5.4
通讯作者：
Cho, HY
中科院分区：
文献类型：
--
作者：
Jung, CH;Seog, HM;Cho, HY
本研究的目的是检查野生人参叶提取物摄入量对链脲佐菌素 (STZ) 诱导的糖尿病大鼠 (WGLE) 可能的抗氧化活性。注射链脲佐菌素后，初始血糖水平突然升高。补充 WGLE 4 周后。饲喂 40 mg/kg (266 mg/dL) 和 200 mg/kg (239 mg/dL) 的动物的血糖水平低于未饲喂 WGLE 的糖尿病大鼠 (464 mg/dL)。补充 WGLE 也降低了血液 TBARS 的浓度，TBARS 被认为是血液中葡萄糖氧化的主要产物。这些结果表明，补充 WGLE 有助于抑制糖尿病大鼠血糖水平的突然升高以及随之而来的 TBARS 水平的降低。 WGLE喂养的糖尿病组的肝脏、肾脏和脾脏中的TBARS水平也显着低于对照糖尿病组，这表明口服WGLE可以有效抑制糖尿病大鼠器官中发生的脂质过氧化。 WGLE 补充剂的抗氧化活性进一步增强，可抑制抗氧化相关酶的活性，例如谷胱甘肽过氧化物酶 (GSH-Px)、过氧化氢酶 (CAT) 和超氧化物歧化酶 (SOD)。在糖尿病大鼠的器官中。这些结果证实了 WGLE 补充剂在解毒糖尿病引起的并发症中过度产生的自由基方面的有效性。 (c) 2005 Elsevier Ireland Ltd. 保留所有权利。
The aim of this study was to examine the possible antioxidant activities of wild Panax ginseng leaf extract intake in streptozotocin (STZ)-induced diabetic rats (WGLE). Initial blood glucose levels increased abruptly after streptozotocin injection. After 4 weeks of WGLE supplementation. blood glucose levels were lower in animals fed 40 mg/kg (266 mg/dL) and 200 mg/kg (239 mg/dL) than those in no-WGLE fed diabetic rats (464 mg/dL). The concentration of blood TBARS, which are considered the main products of glucose oxidation in blood, was also lowered by WGLE supplementation. These results indicate that WGLE supplementation is involved in suppressing a sudden increase in blood glucose levels and a consequent decrease in TBARS levels in diabetic rats. TBARS levels in the liver, kidney and spleen of WGLE-fed diabetic groups were also significantly lower than in the control diabetic group indicating that oral administration of WGLE effectively suppresses lipid peroxidation that occurs in the organs of diabetic rats. Antioxidant activities of WGLE supplementation further extend in suppressing activities of antioxidant related enzymes, such as glutathione peroxidase (GSH-Px), catalase (CAT) and superoxide dismutase (SOD). in organs of diabetic rats. These results confirm the effectiveness of WGLE supplementation in detoxifying free radicals that are produced excessively in diabetic-induced complications. (c) 2005 Elsevier Ireland Ltd. All rights reserved.