Cinnamon extract suppresses tumor progression by modulating angiogenesis and the effector function of CD8+ T cells
Cinnamon extract suppresses tumor progression by modulating angiogenesis and the effector function of CD8+ T cells
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DOI：
10.1016/j.canlet.2009.01.015
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发表时间：
2009-06-18
期刊：
影响因子：
9.7
通讯作者：
Im, Sin-Hyeog
中科院分区：
文献类型：
--
作者：
Kwon, Ho-Keun;Jeon, Won Kyung;Im, Sin-Hyeog
肉桂是最广泛使用的草药之一，具有多种生物活性作用。然而，很少有证据表明肉桂的潜在抗肿瘤作用。在体外和体内系统中，肉桂治疗不仅在黑色素瘤细胞系而且在实验性黑色素瘤模型中强烈抑制促血管生成因子和肿瘤进展的主调节因子的表达。此外，肉桂治疗通过增加细胞溶解分子的水平及其细胞毒活性来增加CD8（+）T细胞的抗肿瘤活性。总之，肉桂提取物具有成为肿瘤治疗的替代药物的潜力。(C)2009爱思唯尔爱尔兰有限公司保留所有权利。
Cinnamon is one of the most widely used herbal medicines with diverse bioactive effects. However, little evidence has been reported about the potential anti-tumor effects of cinnamon. In vitro and in vivo system, cinnamon treatment strongly inhibited the expression of pro-angiogenic factors and master regulators of tumor progression not only in melanoma cell lines but also in experimental melanoma model. In addition, cinnamon treatment increased the anti-tumor activities of CD8(+) T cells by increasing the levels of cytolytic molecules and their cytotoxic activity. In conclusion, cinnamon extract has the potential to be an alternative medicine for tumor treatment. (C) 2009 Elsevier Ireland Ltd. All rights reserved.