Tumor Volume, Tumor Percentage Involvement, or Prostate Volume: Which Is Predictive of Prostate-specific Antigen Recurrence?
Tumor Volume, Tumor Percentage Involvement, or Prostate Volume: Which Is Predictive of Prostate-specific Antigen Recurrence?
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DOI：
10.1016/j.urology.2009.06.059
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发表时间：
2010-02-01
期刊：
影响因子：
2.1
通讯作者：
Moul, Judd W.
中科院分区：
文献类型：
--
作者：
Uhlman, Matthew A.;Sun, Leon;Moul, Judd W.
目的比较肿瘤体积（TV）、肿瘤受累百分比（TPI）和前列腺体积（PV）对根治性前列腺切除术（RP）后前列腺特异性抗原（PSA）复发（PSAR）的影响。方法从杜克前列腺中心检索1988年至2008年间接受RP治疗的3528例患者。患者按TV（< 3、3-6、> 6 cm(3)）、TPI（< 10%、10%-20%、> 20%）和PV（< 35、35-45、> 45 cm(3)）分层，并采用Kaplan-Meier分析评估其对PSAR的影响。单因素分析的临床病理变量包括手术年龄、种族、手术年份、PSA、病理Gleason评分、病理肿瘤分期、边缘状态、囊外延伸和精囊侵犯。使用Cox分析比较TV、TPI和PV（作为连续变量和分类变量）对PSAR的影响。结果TPI、TV、PV可预测PSAR （P < 0.05）
OBJECTIVES To compare the effects of tumor volume (TV), tumor percentage involvement (TPI), and prostate volume (PV) on prostate-specific antigen (PSA) recurrence (PSAR) after radical prostatectomy (RP).METHODS A cohort of 3528 patients receiving RP between 1988 and 2008 was retrieved from the Duke Prostate Center. Patients were stratified by TV (< 3, 3-6, > 6 cm(3)), TPI (< 10%, 10%-20%, > 20%), and PV (< 35, 35-45, > 45 cm(3)) and their effects on PSAR evaluated using Kaplan-Meier analysis. Clinicopathologic variables included in univariate analysis were age at surgery, race, year of surgery, PSA, pathologic Gleason score, pathologic tumor stage, margin status, extracapsular extension, and seminal vesicle invasion. The effects of TV, TPI, and PV (as continuous and categorical variables) on PSAR were compared using Cox analysis.RESULTS TPI, TV, and PV were predictive of PSAR (P