Cucurbit[n]urils: from mechanism to structure and function
Cucurbit[n]urils: from mechanism to structure and function
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DOI：
10.1039/b814897j
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发表时间：
2009-01-01
影响因子：
4.9
通讯作者：
Isaacs, Lyle
中科院分区：
文献类型：
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作者：
Isaacs, Lyle
这篇专题文章详细介绍了分子容器葫芦[n]uril家族(CB[n])的一些不寻常的识别特性。它讨论了 CB[n] 形成的机制，该机制是从甘脲通过亚甲基桥接甘脲低聚物进行的，并描述了一些动力学稳定的大环中间体的结构和识别特性。这些部分形成的 CB[n] 型受体（称为nor-seco-CB[n]）显示出有趣的特性，例如手性识别、同向变构，并作为醛反应葫芦脲合成子发挥作用。
This feature article details some of the unusual recognition properties of the cucurbit[n]uril family (CB[n]) of molecular containers. It discusses the mechanism of CB[ n] formation, which proceeds from glycoluril via methylene bridged glycoluril oligomers, along with descriptions of the structures and recognition properties of some kinetically stable macrocyclic intermediates along the way. These partially formed CB[n]-type receptors known as nor-seco-CB[n] display intriguing properties such as chiral recognition, homotropic allostery, and function as aldehyde reaction cucurbituril synthons.