Impact of health on particle size of exhaled respiratory aerosols:: Case-control study
Impact of health on particle size of exhaled respiratory aerosols:: Case-control study
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DOI：
10.1002/clen.200700189
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发表时间：
2008-07-01
影响因子：
1.7
通讯作者：
Freymuth, Francois
中科院分区：
文献类型：
--
作者：
Hersen, Guillaume;Moularat, Stephane;Freymuth, Francois
病毒感染者可能会散发出具有传染性的气溶胶。区分受感染者和健康人的呼出气应有助于了解感染的空气传播。在这种情况下，本研究的目的是区分健康的人从症状的研究他们的呼出气。为了收集呼出气，已经开发了一种由连接到电动低压冲击器的改良罩组成的装置，该装置允许研究宽范围的颗粒尺寸（从7 nm到10 pm）。该装置已用于78名志愿者。使用主成分分析（PCA）得到的结果表明，没有症状的个体的呼出气具有统计相似性，并不同于有症状的个体。这种分离是通过具有在冲击器的第3级（D-50 = 0.09 μ m）、第6级（D-50 = 0.38 μ m）、第8级（D-50 = 0.95 μ m）、第10级（D-50 = 2.40 μ m）和第12级（D-50 = 4.02 μ m）收集的颗粒的症状的个体的更大比例的排放来实现的。没有获得具有症状的个体的特定大小分布。因此，对呼出气的进一步研究应该在有症状的志愿者中进行，并且需要分析这种广泛的颗粒尺寸。
Individuals with viral infection could possibly emit an infectious aerosol. The distinction between exhaled breaths of infected and healthy individuals should facilitate an understanding of the airborne transmission of infections. In this context, the present study is aimed at distinguishing healthy individuals from symptomatic ones by the study of their exhaled breath. A setup composed of a modified hood connected to an electrical low pressure impactor, which allows for the study of a wide range of particle sizes (from 7 nm to 10 pm), has been developed in order to collect exhaled breaths. This setup has been used with seventy eight volunteers. The results obtained using Principal Component Analysis (PCA) showed that exhaled breaths of individuals without symptoms have statistical similarities and are different from those of individuals with symptoms. This separation was made by the greater proportional emission by individuals with symptoms of particles collected on stages 3 (D-50 = 0.09 mu m), 6 (D5o = 0.38 mu m), 8 (D-50 = 0.95 mu m), 10 (D-50 = 2.40 mu m), and 12 (D-50 = 4.02 mu m) of the impactor. There was not a specific size distribution obtained for the individuals with symptoms. As a consequence, further research on the exhaled breath should be undertaken with symptomatic volunteers and would require the analysis of this wide range of particle sizes.