Population history and natural selection shape patterns of genetic variation in 132 genes.
Population history and natural selection shape patterns of genetic variation in 132 genes.
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DOI：
10.1371/journal.pbio.0020286
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发表时间：
2004-10
期刊：
影响因子：
9.8
通讯作者：
Kruglyak L
中科院分区：
文献类型：
--
作者：
Akey JM;Eberle MA;Rieder MJ;Carlson CS;Shriver MD;Nickerson DA;Kruglyak L
对132个人类基因的分析表明，现代人从非洲迁移到新环境的过程伴随着对新出现的选择压力的遗传适应。
Identifying regions of the human genome that have been targets of natural selection will provide important insights into human evolutionary history and may facilitate the identification of complex disease genes. Although the signature that natural selection imparts on DNA sequence variation is difficult to disentangle from the effects of neutral processes such as population demographic history, selective and demographic forces can be distinguished by analyzing multiple loci dispersed throughout the genome. We studied the molecular evolution of 132 genes by comprehensively resequencing them in 24 African-Americans and 23 European-Americans. We developed a rigorous computational approach for taking into account multiple hypothesis tests and demographic history and found that while many apparent selective events can instead be explained by demography, there is also strong evidence for positive or balancing selection at eight genes in the European-American population, but none in the African-American population. Our results suggest that the migration of modern humans out of Africa into new environments was accompanied by genetic adaptations to emergent selective forces. In addition, a region containing four contiguous genes on Chromosome 7 showed striking evidence of a recent selective sweep in European-Americans. More generally, our results have important implications for mapping genes underlying complex human diseases. An analysis of 132 human genes suggests that the migration of modern humans out of Africa into new environments was accompanied by genetic adaptations to emergent selective forces
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影响因子：
9.8
作者：
Fullerton, SM;Bartoszewicz, A;Di Rienzo, A
通讯作者：
Di Rienzo, A
影响因子：
9.8
作者：
Bersaglieri, T;Sabeti, PC;Hirschhorn, JN
通讯作者：
Hirschhorn, JN
影响因子：
2.5
作者：
De Cosmo, S;Tassi, V;Viberti, GC
通讯作者：
Viberti, GC
DOI：
10.1073/pnas.022614799
发表时间：
2002-01-22
影响因子：
11.1
作者：
Gilad, Y;Rosenberg, S;Skorecki, K
通讯作者：
Skorecki, K
影响因子：
64.8
作者：
Crackower, MA;Sarao, R;Penninger, JM
通讯作者：
Penninger, JM