Validity and reproducibility of a self-administered food-frequency questionnaire to assess isoflavone intake in a Japanese population in comparison with dietary records and blood and urine isoflavones
Validity and reproducibility of a self-administered food-frequency questionnaire to assess isoflavone intake in a Japanese population in comparison with dietary records and blood and urine isoflavones
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DOI：
10.1093/jn/131.10.2741
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发表时间：
2001-10-01
影响因子：
4.2
通讯作者：
Tsugane, S
中科院分区：
文献类型：
--
作者：
Yamamoto, S;Sobue, T;Tsugane, S
需要制定有效的食物频率问卷（FFQ）来评估异黄酮的摄入量，以调查其与亚洲国家乳腺癌和前列腺癌发病率较低的可能关联。我们研究了JPHC研究（日本公共卫生中心癌症和心血管疾病前瞻性研究）中使用的自给药半定量FFQ中异黄酮（大豆黄酮和染料木素）摄入量的有效性和可重复性。我们还调查了足以确保有效性和可重复性的食品项目的数量。我们收集了215名JPHC研究参与者的FFQ、饮食记录（DR）、血液和尿液样本，估计了FFQ和DR的异黄酮摄入量，并测量了血清异黄酮浓度和尿异黄酮排泄。从FFQ和DR、血清浓度和尿排泄中估计的大豆素平均摄入量分别为18.3 mg/d、14.5 mg/d、119.9 nmol/L和17.0 μ mol/d，染料木素平均摄入量分别为31.4 mg/d、23.4 mg/d、475.3 nmol/L和14.2 μ mol/d。按性别分析的结果相似。经能量调整后的FFQ大豆苷元摄入量与DR大豆苷元摄入量、血清浓度和肌酐调整后尿排泄量的Spearman相关系数分别为0.64、0.31和0.43。两个FFQ估计值在1-y区间的相关性为0.76。染料木黄酮的结果相似。短版本的FFQ有三个项目（味噌汤的纳豆，味噌和豆腐）显示出类似的相关性。原始FFQ和较短版本具有足够的有效性和可重复性，可用于流行病学研究。
Valid food-frequency questionnaires (FFQ) need to be developed to assess isoflavone intake in investigations of its possible association with the lower Incidence of breast and prostate cancer in Asian countries. We investigated the validity and reproducibility of isoflavone (daidzein and genistein) intakes from self-administered semiquantitative FFQ used in the JPHC Study (Japan Public Health Center-based Prospective Study on Cancer and Cardiovascular Diseases). We also investigated the number of food items that would be sufficient to ensure validity and reproducibility. We collected FFQ, dietary records (DR), blood and urine samples from 215 subjects among JPHC Study participants, estimated isoflavone Intakes from FFQ and DR, and measured serum Isoflavone concentration and urine isoflavone excretion. For daidzein, mean intakes estimated from FFQ and DR, serum concentration and urine excretion were 18.3 mg/d, 14.5 mg/d, 119.9 nmol/L and 17.0 mu mol/d and for genistein, 31.4 mg/d, 23.4 mg/d, 475.3 nmol/L and 14.2 mu mol/d, respectively. Results were similar when analyzed by sex. Spearman correlation coefficients for daidzein of energy-adjusted intakes from FFQ with those from DR, serum concentration and creatinine-adjusted urinary excretion were 0.64, 0.31 and 0.43, respectively. Correlations between two FFQ estimates with a 1-y interval were 0.76. Results were similar for genistein. The shorter version of the FFQ with three Items (natto, miso and tofu for miso soup) showed a similar correlation. The original FFQ and the shorter versions have sufficient validity and reproducibility to be used in epidemiologic studies.