brother of rhomboid, a rhomboid-related gene expressed during early Drosophila oogenesis, promotes EGF-R/MAPK signaling
brother of rhomboid, a rhomboid-related gene expressed during early Drosophila oogenesis, promotes EGF-R/MAPK signaling
复制标题
DOI：
10.1006/dbio.2000.9851
复制
发表时间：
2000-10-15
影响因子：
2.7
通讯作者：
Bier, E
中科院分区：
文献类型：
--
作者：
Guichard, A;Roark, M;Bier, E
果蝇菱形（rho）基因参与局部激活EGF受体信号在各种发育环境。已提出Rhomboid蛋白促进膜结合Spitz（mSpi）EGF相关配体的呈递和/或加工以产生配体的活性扩散形式。在这里，我们报告了一个新的菱形相关基因，我们命名为菱形兄弟（brho）的序列相似性搜索。与rho相反，rho在发育的许多阶段以复杂的模式表达，brho似乎只在卵子发生期间表达。brho转录物存在于早期卵母细胞中，并邻接显示高水平MAPK活化的后卵泡细胞。与rho一样，Brho与星星合作通过EGF-R/MAPK途径促进信号传导，遗传证据表明Brho可以激活翅膀中的mSpi和Grk前体EGF配体。我们建议，内源性brho可能激活卵母细胞特异性Gurken配体，从而参与定义后细胞的命运在早期滤泡上皮。(C)北京大学出版社.
The Drosophila rhomboid (rho) gene participates in localized activation of EGF-receptor signaling in various developmental settings. The Rhomboid protein has been proposed to promote presentation and/or processing of the membrane-bound Spitz (mSpi) EGF-related ligand to generate an active diffusible form of the ligand. Here, we report on a new rhomboid-related gene identified by sequence similarity searching that we have named brother of rhomboid (brho). In contrast to rho, which is expressed in complex patterns during many stages of development, brho appears to be expressed only during oogenesis. brho transcripts are present in early oocytes and abut posterior follicle cells which exhibit high levels of MAPK activation. brho, like rho, collaborates with Star to promote signaling through the EGF-R/MAPK pathway, and genetic evidence indicates that Brho can activate both the mSpi and the Grk precursor EGF ligands in the wing. We propose that endogenous brho may activate the oocyte-specific Gurken ligand and thereby participate in defining posterior cell fates in the early follicular epithelium. (C) 2000 Academic Press.