Recent life events, cortisol, dehydroepiandrosterone and the onset of major depression in high-risk adolescents
Recent life events, cortisol, dehydroepiandrosterone and the onset of major depression in high-risk adolescents
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DOI：
10.1192/bjp.177.6.499
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发表时间：
2000-12-01
影响因子：
10.5
通讯作者：
Altham, PME
中科院分区：
文献类型：
--
作者：
Goodyer, IM;Herbert, J;Altham, PME
目前尚不清楚皮质醇或脱氢表雄酮（DHEA）高分泌是否会增加不良生活事件存在时发生重度抑郁症的风险。目的探讨是否存在一种特定的心理内分泌因素预测重度抑郁症的发生。方法对180例精神病理高危青少年（男生73例，女生107例）进行皮质醇、脱氢表雄酮（DHEA）、抑郁症状的评估。入学时和12个月后的生活事件和精神障碍。结果重度抑郁可通过以下因素的加性效应预测：重度抑郁症状加重；个人的失望和失落只在发病前一个月；08:00时的一个或多个皮质醇水平或20:00时的脱氢表雄酮水平高于日平均值的第80个百分位数。结论青少年的一个亚群可能具有重性抑郁症的生理风险，这可能是遗传和/或早期的社会心理原因。
Background It is not clear whether cortisol or dehydroepiandrosterone (DHEA) hypersecretion increases the risk for major depression in the presence of undesirable life events.Aims To determine whether there is a specific pattern of psychoendocrine factors that predicts the onset of major depressive disorder.Method 180 adolescents(73 boys, 107 girls) at high risk for psychopathology were assessed for cortisol, DHEA, depressive symptoms. life events and psychiatric disorder at entry and 12 months later.Results Major depression was predicted for both genders by the additive effects of: higher depressive symptoms; personal disappointments and losses only in-the month before onset; one or more daily levels of cortisol at 08.00 h or DHEA at 20.00 h greater than the 80th percentile of the daily mean.Conclusions A subgroup of adolescents may carry a physiological risk for major depression which may be either of genetic and/or earlier psychosocial origin.