Blocking the negative effects of pyridoxine on patients receiving levodopa.
Blocking the negative effects of pyridoxine on patients receiving levodopa.
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阻断吡哆醇对接受左旋多巴的患者的负面影响。
DOI：
10.1001/jama.1971.03180220084025
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发表时间：
1971
期刊：
影响因子：
--
通讯作者：
P. Papavasiliou
中科院分区：
文献类型：
--
作者：
G. C. Cotzias;P. Papavasiliou
-Duvoisin等人1报道，服用吡哆醇可能会取消左旋多巴的治疗和副作用。这一点在几个中心得到了证实，包括我们自己的。2因此，工业界生产并销售了一种不含吡哆醇的制剂(拉奥贝克)，它涵盖了接受左旋多巴治疗的患者对维生素的需求。在继续我们的外周代谢抑制剂D，L-α-甲基多巴肼或MK485，3的实验时，我们注意到，口服抑制剂和左旋多巴的组合可以控制每天的表现变化。这样的组合也减少了我们的一些患者在其他方面经历的显著的餐后症状重新出现。2，3因此，我们被鼓励测试该抑制剂是否能阻断给予吡哆醇的不良反应。7名患者在新陈代谢病房接受联合治疗时，口服吡哆醇(每天三次，最多100毫克)至少一周。
To the Editor.— Duvoisin et al 1 reported that administration of pyridoxine may cancel the therapeutic and the side effects of levodopa. This was confirmed in several centers, including our own. 2 Consequently, industry produced and marketed a pyridoxine-free preparation (Larobec) which covers needs for vitamins in patients receiving levodopa. While continuing our experiments with the peripheral metabolic inhibitor D, L-alpha-methyl dopahydrazine or MK 485, 3 we noted that diurnal variations in performance could be controlled with orally administered combinations of inhibitor and levodopa. Such combinations have also diminished the striking postprandial reemergence of symptoms otherwise experienced by some of our patients. 2,3 We were thus encouraged to test whether the inhibitor blocked the adverse effects of administered pyridoxine. Pyridoxine (up to 100 mg three times each day) was given orally to seven patients for at least one week while they were in a metabolic ward and were receiving combinations