Cohort Profile: The Tasmanian Longitudinal Health STUDY (TAHS)
Cohort Profile: The Tasmanian Longitudinal Health STUDY (TAHS)
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DOI：
10.1093/ije/dyw028
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发表时间：
2017-04-01
影响因子：
7.7
通讯作者：
Dharmage, Shyamali C.
中科院分区：
文献类型：
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作者：
Matheson, Melanie C.;Abramson, Michael J.;Dharmage, Shyamali C.
塔斯马尼亚纵向健康研究（TAHS），最初命名为塔斯马尼亚哮喘调查，旨在调查儿童哮喘的患病率和自然史。1 1967年，塔斯马尼亚卫生部长（学校卫生服务负责人）批准对澳大利亚塔斯马尼亚岛州1961年出生并上学的所有儿童进行调查。调查的最初目的是提供儿童哮喘的流行病学描述，儿童哮喘具有可变的自然史，需要：（一）估计其在适当年龄儿童中的流行率;（二）估计个人在任何特定时期内改变疾病状态的概率;及（iii）任何长期趋势的估计，最初的研究队列由1961年出生的所有塔斯马尼亚学龄儿童组成，他们在基线调查时年龄为7岁。这是：（i）确保参与者年龄足够大，可以充分进行肺量测定操作;（ii）确保参与者足够年轻，可以通过学校系统进行至少7年的随访;（iii）通过将回忆时间限制在最长7年，减少父母对早期生活暴露和症状的回忆错误。在基线调查中，还收集了父母和所有兄弟姐妹的问卷，使TAHS成为世界上第一个也是最大的呼吸系统疾病家庭研究之一。自基线调查以来，对这一组进行了几次跟踪，概述如下。最初的研究人员计划在1968年研究的4年内招募另一组7岁儿童，以调查哮喘发病率的长期趋势，但从未进行过。
The Tasmanian Longitudinal Health Study (TAHS), originally named the Tasmanian Asthma Survey, was initiated to examine the prevalence and natural history of asthma in childhood. 1 In 1967 the Tasmanian Health Minister, who was the head of the School Health Service, gave his approval to carry out the survey on all children born in 1961 and attending school in the island state of Tasmania, Australia. The original aims of the survey were to provide an epidemiological description of childhood asthma, which has a variable natural history requiring:(i) an estimate of its prevalence among children of a suitable age;(ii) an estimate of the probability that an individual will change disease status during any given period; and (iii) an estimate of any secular trend, specifically any tendency for the incidence to vary over time.The original study cohort consisted of all Tasmanian school children born in 1961, who would be aged 7 years at the time of the baseline survey. This was:(i) to ensure that participants were old enough to adequately perform spirometry manoeuvres;(ii) to ensure that participants were young enough to allow for follow-up of at least 7 years through the school system; and (iii) to reduce parental recall error of early life exposures and symptoms by limiting the recall time to a maximum of 7 years. At the baseline survey, questionnaires on both parents and all siblings were also collected, making the TAHS one of the first and largest family studies of respiratory disease in the world. Since the baseline survey, the cohort has been followed up several times as outlined below. The original study investigators planned to recruit another cohort of 7-year-old children in 4 years from the 1968 study, to investigate secular trends in asthma incidence, but this was never undertaken.