Prevalence of congenital cardiovascular malformations varies by race and ethnicity
Prevalence of congenital cardiovascular malformations varies by race and ethnicity
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DOI：
10.1016/j.ijcard.2009.03.054
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发表时间：
2010-09-03
影响因子：
3.5
通讯作者：
Brumberg, Heather L.
中科院分区：
文献类型：
--
作者：
Mangones, Tania;Manhas, Amitoz;Brumberg, Heather L.
背景：先天性心血管畸形 (CCVM) 是先天性缺陷的最常见形式，导致新生儿发病和死亡，但有关 CCVM 与种族之间关系的信息有限。本研究旨在按种族和民族确定纽约州 (NYS) 哈德逊河谷地区 (HVR) 先天性心血管畸形 (CCVM) 的患病率。方法：纽约州卫生部生命统计和先天性畸形登记数据按种族和民族 (1992-2001) 在 HVR 中获得。 2岁以下确诊的活产病例纳入出生年份登记。患病率是根据种族/民族特定出生情况计算的。使用泊松回归模型进行分析，按种族、时间和县调整活产数。结果：235,230 名出生人口中的 2303 名儿童有 3075 名 CCVM。 CCVM 的总体患病率在非西班牙裔白人（NHW；14.4/1000 活产）中最高，其次是非西班牙裔黑人（12.8/1000 活产）、其他人（12.5/1000 活产），然后是西班牙裔（8.8/1000 活产）。同样，西班牙裔所有 CCVM 的风险率最低。除左心发育不全综合征和动脉导管未闭外，西班牙裔美国人在每个 CCVM 类别中的风险均低于 NHW。时间和区域差异很小。结论：在 HVR 中，所有 CCVM 和特定异常在 NHW 中的患病率最高，而西班牙裔人始终保持较低的风险。 (C) 2009 Elsevier Ireland Ltd. 保留所有权利。
Background: Congenital cardiovascular malformations (CCVMs) are the most common forms of congenital defects, contributing to morbidity and mortality in neonates but information on the association of CCVMs and race is limited. This study aims to determine prevalence of congenital cardiovascular malformations (CCVMs) in the Hudson Valley Region (HVR) of NY State (NYS) by race and ethnicity.Methods: NYS Department of Health Vital Statistics and Congenital Malformations Registry data were obtained by race and ethnicity (1992-2001) across the HVR. Live-birth cases that were diagnosed up to 2 years of age were included in year-of-birth registration. Prevalence was calculated using race/ethnic specific births. Poisson regression models, adjusting for number of live births by race, time and county, as specified were used for analysis.Results: There were 3075 CCVMs of 2303 children from a birth population of 235,230. Overall prevalence of CCVMs was highest for Non-Hispanic White (NHW; 14.4/1000 live births) followed by Non-Hispanic Black (12.8/1000 live births), Others (12.5/1000 live births), and then Hispanics (8.8/1000 live births). Similarly, the risk ratio of all CCVMs was lowest for Hispanics. Hispanics had a lower risk as compared to NHW in each CCVM category except with hypoplastic left heart syndrome and patent ductus arteriosus. There were minimal temporal and regional differences.Conclusions: In the HVR, all CCVMs and specific anomalies have the highest prevalence in NHW with Hispanics consistently maintaining a lower risk. (C) 2009 Elsevier Ireland Ltd. All rights reserved.