Early social isolation disrupts latent inhibition and increases dopamine D2 receptor expression in the medial prefrontal cortex and nucleus accumbens of adult rats
Early social isolation disrupts latent inhibition and increases dopamine D2 receptor expression in the medial prefrontal cortex and nucleus accumbens of adult rats
复制标题
早期社会隔离破坏成年大鼠内侧前额皮质和伏核的潜在抑制并增加多巴胺 D2 受体表达
DOI：
10.1016/j.brainres.2012.01.058
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发表时间：
2012-04-04
期刊：
影响因子：
2.9
通讯作者：
Wang, Weiwen
中科院分区：
文献类型：
--
作者：
Han, Xiao;Li, Nanxin;Wang, Weiwen
青春期是神经发育的关键时期。本研究观察了青春期社会隔离对幼年大鼠内侧前额叶皮质(MPFC)和伏核(NAC)潜伏期抑制(LI)和多巴胺02受体表达的影响。雄性SD大鼠随机分为青春期隔离(ISO；隔离住房，21-34日龄)和社会住房(SOC)组。李在出生后第56天接受了测试。行为学检测后，用免疫组织化学方法检测多巴胺D2受体表达细胞的数量。青少年的社会隔离损害了LI，增加了mPFC和NAC中表达D2受体的细胞数量。结果表明，青春期社会隔离对成年大鼠的认知和多巴胺能功能有深远的影响，可作为多种神经发育障碍的动物模型。(C)2012爱思唯尔B.V.保留所有权利。
Adolescence is a critical period for neurodevelopment. In the present study, we investigated the effects of pen-adolescent social isolation on latent inhibition (LI) and dopamine 02 receptor expression in the medial prefrontal cortex (mPFC) and nucleus accumbens (NAc) of young adult rats. Male Sprague-Dawley rats were randomly divided into adolescent isolation (ISO; isolated housing, 21-34 days of age) and social housing (SOC) groups. LI was tested at postnatal day 56. After behavioral testing, the number of dopamine D2 receptor-expressing cells was determined using immunohistochemistry. Adolescent social isolation impaired LI and increased the number of cells expressing the D2 receptor in the mPFC and NAc. The results suggest that adolescent social isolation produces profound effects on cognitive and dopaminergic function in adult rats, and could be used as an animal model of various neurodevelopmental disorders. (C) 2012 Elsevier B.V. All rights reserved.