Incidence of NIDDM and the natural history of IGT in Pacific and Indian Ocean populations.
Incidence of NIDDM and the natural history of IGT in Pacific and Indian Ocean populations.
复制标题
太平洋和印度洋人群中 NIDDM 的发病率和 IGT 的自然史。
DOI：
10.1016/s0168-8227(96)90007-8
复制
发表时间：
1996
影响因子：
5.1
通讯作者：
Dowse,GK
中科院分区：
文献类型：
--
作者：
Dowse,GK
在太平洋和印度洋区域的发展中岛屿人口内部和之间，NIDDM和IGT的流行程度差别很大。最近在这些人群中收集了一些纵向数据，以便对发病率进行比较。成人NIDDM的发病率范围从巴布亚新几内亚（PNG）城郊和农村高地人的1.2/1000人年（p.y.）到密克罗尼西亚瑙鲁人的22.5/1000人年和巴布亚新几内亚沿海瓦尼格拉农村人的24.0/1000人年不等。波利尼西亚西萨摩亚人（城市和农村地区分别为16.6 /1000年和5.7/1000年）和种族多样化的毛里求斯人：亚洲印度人（15.8 /1000年）的发病率处于中间水平。非洲裔克里奥尔人（12.2）和中国人（10.4/1000年）。当按年龄和体重指数（BMI）分层时，瓦尼格拉人的发病率高于皮马印第安人，毛里求斯人的发病率高于瑙鲁人。对于基线时患有IGT的受试者，转化为NIDDM的比率从19.0到102.6/1000不等。特别是在对年龄和体重指数进行分层后，很明显，IGT失代偿率在人群之间的差异小于观察到的总发病率。与正常受试者相比，IGT患者转化为NIDDM的相对风险从萨摩亚城市居民的2.1到瑙鲁居民的7.6不等，但大多数估计超过5。
The prevalence of both NIDDM and IGT vary considerably within and between developing island populations of the Pacific and Indian Ocean regions. Longitudinal data have been collected recently in a number of these populations, allowing incidence rates to be compared. The incidence of NIDDM in adults ranged from a low of 1.2/1000 person-years (p.y.) in peri-urban and rural Papua New Guinea (PNG) Highlanders to 22.5/1000 p.y. in Micronesian Nauruans and 24.0/1000 p.y. in the rural Wanigelas of coastal PNG. Intermediate rates were observed in Polynesian Western Samoans (16.6 and 5.7/1000 p.y. in urban and rural areas, respectively) and ethnically diverse Mauritians: Asian Indians (15.8). African-origin Creoles (12.2), and Chinese (10.4/1000 p.y.). When stratified by age and body mass index (BMI), incidence in Wanigelas exceeded rates observed in Pima Indians, and rates in Mauritians were higher than those of Nauruans. For subjects with IGT at baseline, rates of conversion to NIDDM ranged from 19.0 to 102.6/1000 p.y. Particularly after stratifying for age and body mass index, it was apparent that there was less variation between populations in rates of decompensation from IGT than was observed for total incidence. The relative risk of conversion to NIDDM for IGT versus normal subjects ranged from 2.1 in urban Samoans to 7.6 in Nauruans, but most estimates exceeded 5.