DNA mimicry by proteins
DNA mimicry by proteins
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DOI：
10.1042/bst0340317
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发表时间：
2006-04-01
影响因子：
3.9
通讯作者：
Tock, MR
中科院分区：
文献类型：
--
作者：
Dryden, DTF;Tock, MR
最近通过结构和生物物理分析发现，蛋白质可以模拟DNA结构，以抑制通常与DNA结合的蛋白质。DNA磷酸骨架的模仿，核苷酸碱基的氢键性质以及DNA双螺旋的弯曲和扭曲都存在于迄今为止发现的模拟物中。这些模拟物靶向一系列蛋白质和酶，如DNA限制酶、DNA修复酶、DNA促旋酶和核小体和类核蛋白相关蛋白。这些蛋白质DNA模拟物的不寻常性质可能为DNA结合蛋白的靶向抑制剂的设计提供基础。
It has been discovered recently, via structural and biophysical analyses, that proteins can mimic DNA structures in order to inhibit proteins that would normally bind to DNA. Mimicry of the phosphate backbone of DNA, the hydrogen-bonding properties of the nucleotide bases and the bending and twisting of the DNA double helix are all present in the mimics discovered to date. These mimics target a range of proteins and enzymes such as DNA restriction enzymes, DNA repair enzymes, DNA gyrase and nucleosomal and nucleoid-associated proteins. The unusual properties of these protein DNA mimics may provide a foundation for the design of targeted inhibitors of DNA-binding proteins.