THE REACTION OF METHYLARSENICALS WITH THIOLS - SOME BIOLOGICAL IMPLICATIONS
THE REACTION OF METHYLARSENICALS WITH THIOLS - SOME BIOLOGICAL IMPLICATIONS
复制标题
DOI：
10.1016/0162-0134(84)83002-0
复制
发表时间：
1984-01-01
影响因子：
3.9
通讯作者：
REGLINSKI, J
中科院分区：
文献类型：
--
作者：
CULLEN, WR;MCBRIDE, BC;REGLINSKI, J
在中性溶液中，二甲基胂酸和甲基胂酸二钠容易被硫醇还原，生成As（III）、（CH_3）_2AsSR、CH_3As（SR“）_2或.图形 **。(RSH= R '' SH =半胱氨酸、谷胱甘肽、HSCH 2CH 2 OH; RSH = HSCH 2COOH; HSR“SH =二硫苏糖醇、6，8-二硫辛酸。反应通常是化学计量和定量的; HSCH 2COOH是一个例外，显然是动力学的原因。给出了表面机理。这些减少生物甲基化的可能的重要性进行了讨论。
Dimethylarsinic acid and disodium methylarsonate are easily reduced by thiols in neutral solution to give the organosulfur derivatives of As(III), (CH3)2AsSR, CH3As(SR'')2 or .**GRAPHIC**. (RSH = R''SH = cysteine, glutathione, HSCH2CH2OH; RSH = HSCH2COOH; HSR"SH = dithiothreitol, 6,8-dithiooctanoic acid. The reactions are usually stoichiometric and quantitative; HSCH2COOH is an exception, apparently for kinetric reasons. The apparent mechanism is given. The possible importance of these reductions in the biological methylation of As was discussed.