A Comparison of Q-Switched and Long-Pulsed Alexandrite Laser for the Treatment of Freckles and Lentigines in Oriental Patients
A Comparison of Q-Switched and Long-Pulsed Alexandrite Laser for the Treatment of Freckles and Lentigines in Oriental Patients
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DOI：
10.1002/lsm.21045
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发表时间：
2011-02-01
影响因子：
2.4
通讯作者：
Chan, H. H. L.
中科院分区：
文献类型：
--
作者：
Ho, S. G. Y.;Yeung, C. K.;Chan, H. H. L.
背景：Q开关（QS）激光可有效治疗I型和II型皮肤的雀斑和雀斑样痣，且副作用极小。长脉冲（LP）激光被认为更适合于治疗深色皮肤类型。目的：探讨使用QS或LP紫翠宝石激光治疗东方患者雀斑和雀斑样痣的疗效和不良反应。方法：一项在20名随机分配接受单次QS的中国患者中进行的前瞻性裂面研究对它们的面的任一侧进行LP（50纳秒）或LP（100微秒）激光处理。两位设盲医生使用治疗前和治疗后照片的视觉模拟量表评估临床疗效。主观评价采用问卷调查，其中详细的程度疼痛，红斑和水肿持续在治疗过程中，改善和满意度水平在4，8，12 wk.Results：有统计学意义上的色素沉着的改善（P < 0.05），在整个研究中，两组之间没有发现统计学差异。与LP治疗（6%）相比，QS治疗（22%）后更常发现炎症后色素沉着过度。在整个研究期间，大多数患者报告色素沉着中度至显著改善，两种脉宽和相应的高满意率水平。更严重的疼痛，红斑和水肿的经验，在QS Alexandrite treatment.Conclusion：LP Alexandrite是快速，有效的，并进行了较低的风险的不良反应比QS Alexandrite，雀斑和雀斑的去除在较暗的皮肤类型。Lasers Surg. Med. 43：108-113，2011. (C)2011 Wiley-Liss，Inc.
Background: Q-switched (QS) lasers are effective in the treatment of freckles and lentigines in Type I and II skin, with minimal adverse effects. Long pulsed (LP) lasers have been proposed to be more suitable for treatment of darker skin types.Objectives: To investigate the efficacy and adverse effects of using QS or LP Alexandrite laser for the treatment of freckles and lentigines in Oriental patients.Methods: A prospective split-face study of 20 Chinese patients who were randomly assigned to undergo a single QS (50 nanosecond) or LP (100 microseconds) laser treatment to either side of their face was carried out. Two blinded physicians assessed clinical efficacy using visual analogue scales of pre- and post-treatment photographs. Subjective assessment was evaluated using questionnaires which detailed the degree of pain, erythema and edema sustained during treatment, and improvement and satisfaction levels at 4, 8, and 12 weeks.Results: There was statistically significant improvement in pigmentation (P < 0.05) in both groups throughout the study, with no statistical difference found between the groups. Postinflammatory hyperpigmentation was more frequently found after QS treatment (22%), compared to LP treatment (6%). Majority of patients reported moderate to marked improvement in pigmentation throughout the study with both pulse widths, and correspondingly high levels of satisfaction rates. More severe pain, erythema and edema were experienced during QS Alexandrite treatment.Conclusion: LP Alexandrite is quick and effective, and carries a lower risk of adverse effects than QS Alexandrite, for the removal of freckles and lentigines in darker skin types. Lasers Surg. Med. 43:108-113, 2011. (C) 2011 Wiley-Liss, Inc.