Nobiletin Ameliorates the Deficits in Hippocampal BDNF, TrkB, and Synapsin I Induced by Chronic Unpredictable Mild Stress
Nobiletin Ameliorates the Deficits in Hippocampal BDNF, TrkB, and Synapsin I Induced by Chronic Unpredictable Mild Stress
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川陈皮素可改善由慢性不可预测的轻度压力引起的海马 BDNF、TrkB 和突触蛋白 I 的缺陷
DOI：
10.1155/2013/359682
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发表时间：
2013-01-01
影响因子：
--
通讯作者：
Yi, Li-Tao
中科院分区：
文献类型：
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作者：
Li, Jing;Zhou, Ying;Yi, Li-Tao
背景我们先前的研究已经证明，诺贝尔宁可以逆转应激小鼠的行为改变。然而，其抗抑郁样作用与神经营养分子表达的关系仍然未知。本研究旨在探讨Nobiliprazole对慢性轻度不可预知应激大鼠神经营养系统的抗抑郁作用机制。方法.抑郁样快感缺失（评估蔗糖偏好）和血清皮质酮分泌进行了评估，脑源性神经营养因子（BDNF），其原肌球蛋白相关激酶受体B（Trk B），和下游的目标突触蛋白I在海马的表达。结果快感缺失，发生在第2周内，迅速改善了诺贝尔。而氟西汀则需要额外2周才能改善快感缺失。此外，5周的诺必利汀给药显著改善了CNS诱导的血清皮质酮水平升高。此外，我们还发现，NOBILLAND可改善海马BDNF、TrkB和突触蛋白I的表达，而NOBILLAND可改善海马BDNF、TrkB和突触蛋白I的表达。结论.综上所述，这些发现表明，Nobiliprazine产生快速作用的抗抑郁样反应在海马，并意味着BDNF-TrkB通路可能发挥重要作用的抗抑郁样作用的Nobiliprazine。
Background. Our previous study has demonstrated that nobiletin could reverse the behavioral alterations in stressed mice. However, the relation of its antidepressant-like action with neurotrophic molecular expression remains unknown. This study aimed to explore the antidepressant-like mechanism of nobiletin related to the neurotrophic system in rats exposed to chronic unpredictable mild stress (CUMS). Methods. Depressive-like anhedonia (assessed by sucrose preference) and serum corticosterone secretion were evaluated in the CUMS, followed by brain-derived neurotrophic factor (BDNF), its tropomyosin-related kinase receptor B (TrkB), and the downstream target synapsin I expressions in the hippocampus. Results. Anhedonia, which occurred within week 2, was rapidly ameliorated by nobiletin. While fluoxetine needed additional 2 weeks to improve the anhedonia. In addition, nobiletin administration for 5 weeks significantly ameliorated CUMS-induced increase in serum corticosterone levels. Furthermore, we also found that CUMS-induced deficits of hippocampal BDNF, TrkB, and synapsin I were ameliorated by nobiletin. Conclusions. Taken together, these findings suggest that nobiletin produces rapidly acting antidepressant-like responses in the CUMS and imply that BDNF-TrkB pathway may play an important role in the antidepressant-like effect of nobiletin.