Effect of Huayu Tongluo Moxibustion on the Ultrastructure of the Frontal of SVD Rats
Effect of Huayu Tongluo Moxibustion on the Ultrastructure of the Frontal of SVD Rats
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发表时间：
2015
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通讯作者：
Wang Ming-ji
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作者：
Wang Ming-ji
目的：研究化瘀通络灸对SVD大鼠额叶皮质神经元及皮质下白色质髓鞘超微结构的影响。方法：采用4- VO法建立SVD大鼠模型，并通过跳跃实验进行验证。将大鼠分为正常组、模型组、假模型组、药物组和艾灸组。一个月后开始治疗。治疗1个疗程后，电镜观察各组大鼠额叶皮质及皮质下白色质超微结构的变化。结果如下：与正常组和假模型组相比，模型组大鼠皮层神经元变性坏死，数量减少。与模型组比较，药物组和艾灸组神经元形态完整，胞质内细胞器正常，胞膜光滑。与正常组和假模型组比较，模型组髓鞘层开始相互分离，鞘角质层较疏松，出现空泡;药物组和艾灸组髓鞘颜色较模型组深，鞘角质层较模型组致密。结论：化瘀通络灸为艾灸治疗SVD提供了理论依据。
Objective: To study the effect of Huayu Tongluo moxibustion on the ultrastructure of frontal cortex neurons and subcortical white matter myelin sheath of SVD rats. Methods: SVD rat models were established in accordance with 4- VO method and confirmed by the jumping experiment. Then the rats were divided into a normal group,a model group,a sham model group,a medicine group and a moxibustion group. The treatment started one month later. After one course of treatment,Observe the changes of ultrastructure of the cortex and subcortical white matter of the rats' frontal lobes in each group with the electron microscope. Results: Compared with the normal group and the sham model group,it was discovered that the cortex neurons in model group were degenerative and necrotic,and the number was decreased. Compared with the model group,the neurons in medicine group and moxibustion group were morphologically intact with smooth membrane and the cell organs in cytoplasm were normal. Compared with the normal group and the sham model group,it was discovered that the myelin sheath layer of model group began to separate each other leading to looser sheath cuticle and some vacuoles while the myelin sheath color in medicine group and moxibustion group was stained deeper with more compact sheath cuticle compared with the model group. Conclusion: Huayu Tongluo moxibustion provides theoretical basis for treating SVD by moxibustion therapy.