The influence of combretastatin A-4 and vinblastine on interstitial fluid pressure in BT4An rat gliomas
The influence of combretastatin A-4 and vinblastine on interstitial fluid pressure in BT4An rat gliomas
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DOI：
10.1016/s0304-3835(01)00835-7
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发表时间：
2002-04-25
期刊：
影响因子：
9.7
通讯作者：
Dahl, O
中科院分区：
文献类型：
--
作者：
Eikesdal, HP;Landuyt, W;Dahl, O
考布他汀A-4磷酸二钠（CA-4，50 mg/kg腹膜内（i. p.））和长春碱（2 mg/kg i. p.）在BT（4）中评估对间质液压力（IFP）的影响。进一步研究了长春碱的生长抑制作用和荧光标记长春碱（BODIPY-长春碱）的分布，比较了不同体积的肿瘤。CA-4对IFP无显著影响，与肿瘤大小无关，长春碱可增加肿瘤大于8 cm（3）的IFP（P = 0.03）。长春碱仅在2.1 cm（3）以下的肿瘤中产生显著的肿瘤反应（P = 0.03）。尽管肿瘤体积存在差异，但BODIPY-长春碱的分布是不均匀的，具有可比性。我们的结论是，在BT（4）An颈部肿瘤中，长春碱对iFP的影响比CA-4更明显，长春碱可能通过增加IFP来减少随后向实体瘤的药物递送。(C)2002爱思唯尔科学爱尔兰有限公司保留所有权利。
The influence of combretastatin A-4 disodium phosphate (CA-4, 50 mg/kg intraperitoneally (i.p.)) and vinblastine (2 mg/kg i.p.) on interstitial fluid pressure (IFP) was assessed in BT(4)An rat gliomas implanted subcutaneously in the neck. Furthermore the growth inhibitory effect of vinblastine and the distribution of fluorescence-conjugated vinblastine (BODIPY-vinblastine) were investigated, Tumors at different volumes were compared. Whereas CA-4 had no major influence on IFP, independent of tumor size, vinblastine increased the lFP in neoplasms above 8 cm(3) (P = 0.03). Vinblastine yielded a significant tumor response only in tumors below 2.1 cm(3) (P = 0.03), The distribution of BODIPY-vinblastine was heterogeneous and comparable despite tumor volume differences. We conclude that the influence of vinblastine on iFP is more pronounced than that of CA-4 in BT(4)An neck tumors, and that vinblastine may reduce subsequent drug delivery to solid tumors by increasing the IFP. (C) 2002 Elsevier Science Ireland Ltd. All rights reserved.