Effects of green and black tea on hepatic xenobiotic metabolizing systems in the male F344 rat.
Effects of green and black tea on hepatic xenobiotic metabolizing systems in the male F344 rat.
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DOI：
10.3109/00498259409043226
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发表时间：
1994-02
期刊：
影响因子：
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通讯作者：
O. Sohn;A. Surace;Emerich S. Fiala;John P. Richie;Steven Colosimo;E. Zang;John H. Weisburger
中科院分区：
文献类型：
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作者：
O. Sohn;A. Surace;Emerich S. Fiala;John P. Richie;Steven Colosimo;E. Zang;John H. Weisburger
1. 研究了雄性 F344 大鼠饮用 2% (w/v) 绿茶或红茶溶液 6 周后肝脏中 I 相和 II 相酶的诱导情况。还研究了血液、肝脏和肾脏中的谷胱甘肽 (GSH) 和半胱氨酸，以及血清胆固醇、高密度脂蛋白胆固醇、甘油三酯以及总睾酮和游离睾酮。 2.所有组中总一氧化碳可辨别的肝脏P450、b5和NADPH-细胞色素c(P450)还原酶活性相似。 3.饮用绿茶或红茶的大鼠肝脏中P4501A1、1A2和2B1活性显着增加，但P4502E1和3A4活性无变化。在 II 相酶中，UDP-葡萄糖醛酸转移酶增加，但谷胱甘肽 S-转移酶没有增加。 4.红茶组血清GSH较高，其他组GSH和胱氨酸处于对照水平。与绿茶相比，喝红茶的老鼠血清胆固醇较低。与水对照相比，接触绿茶和红茶后甘油三酯呈下降趋势。游离睾酮和总睾酮不受影响。 5. 因此，人类广泛使用的饮料改变了大鼠肝脏中特定 I 相和 II 相酶以及特定血清参数方面的宿主生物化学。
1. The induction of phase I and II enzymes in the liver of the male F344 rat drinking 2% (w/v) solutions of green or black tea for 6 weeks was investigated. Also studied were glutathione (GSH) and cyst(e)ine in blood, liver and kidney, as well as serum cholesterol, HDL cholesterol, triglycerides, and total and free testosterone. 2. The total carbon monoxide-discernible liver P450, b5 and NADPH-cytochrome c(P450) reductase activities were similar in all groups. 3. There were significant increases in liver of rat drinking green or black tea of P4501A1, 1A2 and 2B1 activities, but no change in P4502E1 and 3A4 activities. Of the phase II enzymes, UDP-glucuronyltransferase was increased, but glutathione S-transferase was not. 4. Serum GSH was higher in the group administered black tea, but GSH and cyst(e)ine in other groups was at control levels. Serum cholesterol was lower in rat given black compared with green tea. Triglycerides had a declining trend after green and black tea exposure compared with water controls. Free and total testosterone were not affected. 5. Thus, beverages widely used by man altered host biochemistry as regards specific phase I and II enzymes in liver of rat and specific serum parameters.