LTP in the barrel cortex of adult rats.
LTP in the barrel cortex of adult rats.
复制标题
成年大鼠桶状皮质中的 LTP。
DOI：
10.1097/00001756-199511270-00007
复制
发表时间：
1995
期刊：
影响因子：
1.7
通讯作者：
Keller,A
中科院分区：
文献类型：
--
作者：
Aroniadou-Anderjaska,V;Keller,A
桶状皮层的内在回路已经被证明是容易修改的，以响应感觉输入模式的变化，即使在成年动物。据信，感觉经验通过施加特定的重复突触前和突触后协同活动模式（即LTP样过程）来修改突触回路。然而，成人桶状皮质中的固有突触表达LTP的能力尚未得到证实。在成年大鼠桶形皮层切片中，我们发现，输入特异性LTP可以诱导在颗粒层内的垂直和水平输入的强直刺激。
Intrinsic circuitry in the barrel cortex has been shown to be readily modifiable in response to changes in the patterns of sensory input, even in adult animals. It is believed that sensory experience modifies synaptic circuits by imposing specific patterns of repetitive presynaptic and postsynaptic coactivity, ie by LTP-like processes. However, the ability of intrinsic cynapses in the adult barrel cortex to express LTP has not been demonstrated. In slices from barrel cortex of adult rats, we show that input-specific LTP can be induced in the supragranular layers by tetanic stimulation of intracortical vertical and horizontal inputs.