Relationship Between Retinal Blood Flow and Serum Adiponectin Concentrations in Patients With Type 2 Diabetes Mellitus
Relationship Between Retinal Blood Flow and Serum Adiponectin Concentrations in Patients With Type 2 Diabetes Mellitus
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DOI：
10.1167/iovs.15-16447
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发表时间：
2015-06-01
影响因子：
4.4
通讯作者：
Yoshida, Akitoshi
中科院分区：
文献类型：
--
作者：
Omae, Tsuneaki;Nagaoka, Taiji;Yoshida, Akitoshi
目的.目的探讨2型糖尿病患者视网膜微循环与血清脂联素（adiponectin）浓度的关系。使用激光多普勒测速系统，我们同时测量了64例连续的日本2型糖尿病患者（平均年龄+/- SD，59.8 +/- 10.4岁）的视网膜血流（RBF）值和视网膜血管直径和血流速度，这些患者没有或轻度非增殖性糖尿病视网膜病变。我们比较了这些患者的RBF和血清脂联素浓度的值。根据性别将患者分为两组（33名男性，31名女性）。血浆脂联素浓度与视网膜血管直径呈正相关（r = 0.480; P = 0.005），视网膜血流速度（r = 0.399; P = 0.02），RBF与视网膜动脉血管阻力呈负相关（r = 0.518; P = 0.002）（r = -0.598; P = 0.0002）男性，而不是女性，2型糖尿病与早期糖尿病视网膜病变。多元回归分析显示，血浆脂联素水平与视网膜动脉血流阻力呈独立正相关，与视网膜动脉血流阻力呈负相关。我们的研究结果表明，高浓度的血清脂联素可能与RBF增加有关，这可能是通过2型糖尿病伴早期糖尿病视网膜病变的男性患者的血流速度增加和血管直径扩张来实现的。
PURPOSE. To study the relationship between retinal microcirculation and serum adiponectin, an important adipocytokine secreted by adipocytes, concentrations in patients with type 2 diabetes mellitus.METHODS. Using a laser Doppler velocimetry system, we simultaneously measured the retinal blood flow (RBF) values and retinal vessel diameter and blood velocity in 64 consecutive Japanese patients (mean age +/- SD, 59.8 +/- 10.4 years) with type 2 diabetes with no or mild nonproliferative diabetic retinopathy. We compared the values with the RBF and serum adiponectin concentrations in these patients. The patients were divided into two groups based on sex (33 males, 31 females).RESULTS. The plasma adiponectin concentrations were correlated positively with the retinal vessel diameter (r = 0.480; P = 0.005), retinal blood velocity (r = 0.399; P = 0.02), and RBF (r = 0.518; P = 0.002) and correlated negatively with the retinal arterial vascular resistance (r = -0.598; P = 0.0002) in males, but not females, with type 2 diabetes with early-stage diabetic retinopathy. Multiple regression analysis showed that the plasma adiponectin level was independently and positively correlated with RBF and negatively correlated with retinal arterial vascular resistance.CONCLUSIONS. Our results indicated that a high concentration of serum adiponectin may be associated with increased RBF, probably via the increased blood velocity and dilated vessel diameter in males with type 2 diabetes with early-phase diabetic retinopathy.