Synthesis and photodynamic therapy of mono-mannose modified perylene bisimide bridged permethyl-β-CDs
Synthesis and photodynamic therapy of mono-mannose modified perylene bisimide bridged permethyl-β-CDs
复制标题
单甘露糖修饰苝双酰亚胺桥联全甲基-β-CDs的合成及光动力治疗
DOI：
10.1016/j.dyepig.2016.09.006
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发表时间：
2017-01-01
影响因子：
4.5
通讯作者：
Li, Xiao-Liu
中科院分区：
文献类型：
--
作者：
Cao, Guo-Jing;Rong, Rui-Xue;Li, Xiao-Liu
合成了一种单甘露糖修饰的苝酰亚胺桥连全甲基-β-CD 8，由于全甲基-β-CD的自包结效应，它表现出有趣的溶剂控制手性。此外，化合物8作为光动力治疗剂显示出有效的光动力治疗活性，其对MCF-7、Hela、A549和Hep G2细胞的IC 50值分别为3.96、16.79、6.62和5.14 μ M，优于对照化合物TPPS。流式细胞仪检测结果显示，8诱导的细胞凋亡过程明显。此外，8作为光稳定性分子显示与MCF-7细胞的荧光成像。8作为一种新型的PDT分子，显示出高的光细胞毒性和活细胞成像应用。(C)2016爱思唯尔有限公司版权所有。
A mono-mannose modified perylene bisimide bridged permethyl-beta-CDs 8 was synthesized, which showed interestingly solvent-controlled chirality because of self-inclusion effect of permethyl-beta-CD. Furthermore, compound 8 as photodynamic therapy agent exhibited potent photodynamic therapy activities with the IC50 values of 3.96, 16.79, 6.62 and 5.14 mu M against MCF-7, Hela, A549 and Hep G2 cells, respectively, better than the control compound TPPS. Then the mechanism of the cell death induced by 8 was investigated by flow cytometric analysis, obvious apoptosis process was observed. Moreover, 8 as photostability molecule showed fluorescent imaging with the MCF-7 cells. 8 as a novel PDT molecule showed high pohotocytotoxicity and live cell imaging applications. (C) 2016 Elsevier Ltd. All rights reserved.