Protein intake, brain amino acid and serotonin concentrations and protein self-selection.
Protein intake, brain amino acid and serotonin concentrations and protein self-selection.
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DOI：
10.1093/jn/119.5.677
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发表时间：
1989-05
期刊：
影响因子：
--
通讯作者：
A. E. Harper;John C. Peters
中科院分区：
文献类型：
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作者：
A. E. Harper;John C. Peters
对膳食蛋白质含量、脑氨基酸和血清素浓度以及大鼠蛋白质自我选择之间关联的证据的分析表明：1）蛋白质摄入量没有受到精确调节，尽管大鼠会在低蛋白和高蛋白饮食之间进行选择以获得足够但不过量的蛋白质； 2）大脑血清素浓度与蛋白质摄入量之间的关联较弱，尽管单餐摄入缺乏蛋白质的饮食会提高大脑血清素浓度； 3）驱使老鼠避免摄入蛋白质不足或过量的饮食的信号的本质仍然不清楚； (4) 由于氨基酸之间跨血脑屏障的竞争摄取以及血液氨基酸浓度的有效代谢调节，全脑氨基酸和血清素浓度在通常的蛋白质摄入量范围内相当稳定； 5）蛋白质摄入和偏好本身不受调节，但摄入和偏好的调节似乎反映了控制血浆氨基酸浓度的系统的反应； (6) 自我选择大鼠组的平均蛋白质摄入量的相对稳定性（这给出了调节的外观）是由于大鼠对蛋白质含量不同的饮食所产生的各种感官线索的可变行为反应（习得的厌恶和偏好）进行平均而得到的。
Analysis of evidence of associations among dietary protein content, brain amino acid and serotonin concentrations, and protein self-selection by rats suggests that 1) protein intake is not regulated precisely, although rats will select between low and high protein diets to obtain an adequate, but not excessive, amount of protein; 2) associations between brain serotonin concentration and protein intake are weak, although consumption of single meals of protein-deficient diets will elevate brain serotonin concentration; 3) the nature of signals that drive rats to avoid diets containing inadequate or excessive amounts of protein remains obscure; (4) whole brain amino acid and serotonin concentrations are quite stable over the usual range of protein intakes, owing to competition among amino acids for uptake across the blood-brain barrier and effective metabolic regulation of blood amino acid concentrations; 5) protein intake and preference are not in themselves regulated, but what appears to be regulation of intake and preference is a reflection of the responses of systems for control of plasma amino acid concentrations; and (6) the relative stability of the average protein intake of groups of self-selecting rats (which gives the appearance of regulation) results from averaging the variable behavioral responses--learned aversions and preferences--of rats to the variety of sensory cues arising from diets that differ in protein content.