Chemical and behavioral control of breathing in adult twins.
Chemical and behavioral control of breathing in adult twins.
复制标题
成年双胞胎呼吸的化学和行为控制。
DOI：
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发表时间：
1984
期刊：
影响因子：
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通讯作者：
A. Shida
中科院分区：
文献类型：
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作者：
Y. Kawakami;H. Yamamoto;T. Yoshikawa;A. Shida
在28对同卵双胞胎（平均年龄40 +/- SD 9.9岁）和10对异卵双胞胎（35 +/- 9.3岁）中，研究了遗传对成年后呼吸的化学和行为控制是否仍然存在影响。低氧和高碳酸血症通气反应的平均值、感知吸入阻力增加的阈值和呼吸模式在同卵双胞胎和异卵双胞胎之间没有差异。然而，低氧反应（4.08,p < 0.005）、高糖血症反应（4.89,p < 0.005）、呼吸频率（3.96,p < 0.005）、吸气时间（5.47,p < 0.005）、缺氧时吸气时间（9.08,p < 0.005）的对内方差比（以单卵双胞胎为分母）均显著大于1。两组间高碳酸血症时阻力负荷感知阈值和呼吸模式的对内方差相等。这些结果表明，呼吸空气时对低氧和高碳酸血症的通气反应和呼吸模式包括遗传决定因素，而在高碳酸血症期间增加阻力和呼吸模式的感知阈值主要受成年期环境力的影响。
Whether genetic influence on chemical and behavioral control of breathing is still present in adulthood was examined in 28 pairs of monozygotic (mean age, 40 +/- SD 9.9 yr) and 10 dizygotic (35 +/- 9.3 yr) twins. Mean values for hypoxic and hypercapnic ventilatory responses, threshold for perceiving added inspiratory resistance, and respiratory patterns were not different between monozygotic and dizygotic twins. However, within-pair variance ratios (those in monozygotic twins being denominators) for hypoxic response (4.08, p less than 0.005), hypercapnic response (4.89, p less than 0.005), respiratory frequency during air breathing (3.96, p less than 0.005), inspiratory time during air breathing (5.47, p less than 0.005), and inspiratory time during hypoxia (9.08, p less than 0.005) were significantly larger than 1. Within-pair variances for threshold for resistive load perception and respiratory pattern during hypercapnia were equivalent between the 2 groups. These results indicate that ventilatory responses to hypoxia and hypercapnia and respiratory patterns while breathing air include genetically determined factors, whereas perception threshold for added resistance and respiratory patterns during hypercapnia are influenced predominantly by environmental force in adulthood.