AnnexinA5 promote glioma cell invasion and migration via the PI3K/Akt/NF-κB signaling pathway
AnnexinA5 promote glioma cell invasion and migration via the PI3K/Akt/NF-κB signaling pathway
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AnnexinA5 通过 PI3K/Akt/NF-kappa B 信号通路促进胶质瘤细胞侵袭和迁移
DOI：
10.1007/s11060-018-2818-4
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发表时间：
2018-07-01
影响因子：
3.9
通讯作者：
Wu, Lei
中科院分区：
文献类型：
--
作者：
Ji, Chenxing;Guo, Hua;Wu, Lei
AnnexinA5作为Annexins的重要成员，在滋养细胞膜修复、抗凝和细胞信号转导等方面发挥着重要作用。大量研究表明，AnnexinA5与多种癌症密切相关。然而，AnnexinA5在胶质瘤癌症进展中的潜在作用仍不清楚。在这项研究中，我们报告了AnnexinA5在高级别胶质瘤样本和胶质瘤细胞系中显著上调。此外，AnnexinA5的过表达促进了细胞在体外的迁移和侵袭，并促进了胶质瘤细胞在裸鼠体内的致瘤性，而AnnexinA5的敲除在这些细胞过程中表现出抑制作用。重要的是，机制研究进一步揭示了AnnexinA5通过激活PI3K/Akt/NF-kappa B信号通路是Snail必不可少的转录靶点。综上所述，这些发现提示AnnexinA5或PI3K/Akt/NF-kappa B通路可能是根除胶质瘤转移的有希望的治疗分子。
As an important member of the Annexins, AnnexinA5 has been attributed important functions in trophoblast membrane repair, anticoagulation and cellular signal transduction. Accumulated studies show that AnnexinA5 is closely associated with various types of carcinomas. However, the potential contribution of AnnexinA5 to glioma cancer progression remains unclear. In this study, we report that AnnexinA5 is significantly upregulated in both high-grade glioma samples and glioma cell lines. Moreover, overexpression of AnnexinA5 promotes cell migration and invasion in vitro and tumorigenicity of glioma cells in nude mice, while knockdown of AnnexinA5 manifests a repressive function during these cellular processes. Importantly, mechanistic studies further reveal that AnnexinA5 is an essential transcriptional target of Snail via activating the PI3K/Akt/NF-kappa B signaling pathway. Taken together, these findings suggest that AnnexinA5 or the PI3K/Akt/NF-kappa B pathway may be promising therapeutic molecules to eradicate glioma metastases.