Epidemiology of Herpes Zoster and Its Relationship to Varicella in Japan: A 10-Year Survey of 48,388 Herpes Zoster Cases in Miyazaki Prefecture
Epidemiology of Herpes Zoster and Its Relationship to Varicella in Japan: A 10-Year Survey of 48,388 Herpes Zoster Cases in Miyazaki Prefecture
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DOI：
10.1002/jmv.21599
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发表时间：
2009-12-01
影响因子：
12.7
通讯作者：
Shiraki, Kimiyasu
中科院分区：
文献类型：
--
作者：
Toyama, Nozomu;Shiraki, Kimiyasu
从1997年到2006年，共有48388名带状疱疹患者，从3个月大的女婴到102岁的老妇人，在人口约120万的宫崎县的46家皮肤科诊所接受了监测。各年龄组带状疱疹平均发病率为4.15/ 1000人-年，差异在1.96 ~ 7.84/ 1000人-年之间，女性发病率（4.58）明显高于男性发病率（3.67）。各年龄组发病率50岁以下为1.96 ~ 2.86/ 1000人-年，50-59岁及以上为5.23 ~ 7.84/ 1000人-年，30-39岁为低谷，形成小高峰和大高峰。女性发病率明显高于男性，40岁以下性别差异较小，但40-49岁、50-59岁和60-69岁性别差异较大。带状疱疹的发病率在8月最高，冬季最低，与水痘的发病率一致。从1997年到2006年，60岁及以上人群中带状疱疹病例的数量比人口中增加得更多，而60-69岁及以上人群中带状疱疹发病率的增加，特别是在女性中，与60岁以下的稳定发病率相比，可能提高了发病率。这项大规模调查阐明了日本宫崎县按年龄、性别和季节划分的带状疱疹流行病学与水痘流行率的关系。中华医学杂志，2009,31(1):357 - 357。(C) 2009 Wiley-Liss, Inc。
From 1997 to 2006, a total of 48,388 patients with herpes zoster, ranging from a 3-month-old girl to a 102-year-old woman, were monitored at the 46 dermatology clinics in the Miyazaki Prefecture, which has a population of about 1.2 million. The mean herpes zoster incidence was 4.15/1,000 person-years, ranging from 1.96 to 7.84/1,000 person-years among different age groups, and the herpes zoster incidence was significantly higher in females (4.58) than in males (3.67). The incidence by age group was 1.96-2.86/1,000 person-years below the age of 50 years, and it increased to 5.23-7.84/1,000 person-years in persons 50-59 and older, with a trough in the ages 30-39, forming the small and large peaks. Females showed a significantly higher incidence than males, and the difference between the sexes was small below age 40 but greater at 40-49, 50-59, and 60-69. The incidence of herpes zoster was highest in August and lowest in winter, mirroring the prevalence of varicella. The number of herpes zoster cases at 60 years and older increased more than in the population from 1997 to 2006, and this increased incidence of herpes zoster in the 60-69 years and older, especially in females, might have raised the rate in contrast to the stable incidence below the age of 60 years. This large-scale survey clarifies the epidemiology of herpes zoster by age, gender, and season in relation to the prevalence of varicella in the Miyazaki Prefecture in Japan. J. Med. Virol. 8 1:2053-2058, 2009. (C) 2009 Wiley-Liss, Inc.