Pure non-gestational choriocarcinoma of the ovary diagnosed by DNA polymorphism analysis
Pure non-gestational choriocarcinoma of the ovary diagnosed by DNA polymorphism analysis
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DOI：
10.1111/j.1440-1827.2006.02016.x
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发表时间：
2006-10-01
影响因子：
2.2
通讯作者：
Kim, Jong-Hyuk
中科院分区：
文献类型：
--
作者：
Koo, Hyun-Lyoung;Choi, Jene;Kim, Jong-Hyuk
单纯原发性卵巢绒毛膜癌是一种罕见的情况，可以是妊娠或非妊娠起源。非妊娠性绒毛膜癌对单药化疗耐药，预后比妊娠性绒毛膜癌差，但常规组织学检查难以区分两者。本文报告一位33岁未孕妇女原发性非妊娠性卵巢绒毛膜癌的病例，经DNA多态性分析证实。所有检测的微卫星标记在患者的肿瘤和子宫肌层之间具有相同的等位基因大小的相同DNA谱，患者的三个标记（BAT26、BAT25和D17S250）为纯合，四个标记（D2S123、D18S57、DCC和D18S58）为杂合，支持非妊娠起源。患者在手术后17个月和四个周期的联合化疗后没有疾病的证据。本病例证明DNA多态性分析对确定子宫外绒毛膜癌起源的有用性。这种方法的临床相关性需要进一步研究和证实。
Pure primary ovarian choriocarcinoma is a rare condition that can be of gestational or non-gestational origin. Non-gestational choriocarcinoma has been found to be resistant to single-agent chemotherapy and has a worse prognosis than gestational choriocarcinoma, but it is difficult to distinguish the two types by routine histological examination. Herein is reported a case of primary pure non-gestational choriocarcinoma of the ovary in a 33-year-old nulligravid woman, as confirmed by DNA polymorphism analysis. All tested microsatellite markers had identical DNA profiles with the same allelic sizes between the tumor and the myometrium of the patient, who was homozygous for three markers (BAT26, BAT25 and D17S250) and heterozygous for four (D2S123, D18S57, DCC and D18S58), supporting non-gestational origin. The patient has no evidence of disease 17 months after surgery and four cycles of combination chemotherapy. This case demonstrates the usefulness of DNA polymorphism analysis for the determination of the origin of extrauterine choriocarcinoma. Clinical relevance of this method needs to be further studied and substantiated.