Ezrin is Associated with Gastric Cancer Progression and Prognosis
Ezrin is Associated with Gastric Cancer Progression and Prognosis
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DOI：
10.1007/s12253-011-9402-y
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发表时间：
2011-12-01
影响因子：
2.8
通讯作者：
Ma, Jie
中科院分区：
文献类型：
--
作者：
Li, Li;Wang, Yuan-Yu;Ma, Jie
探讨Ezrin在胃癌发生发展中的临床意义。应用免疫组化方法检测436例胃癌组织中Ezrin的表达。Ezrin蛋白在胃癌组织中表达水平高于癌旁组织。Ezrin的阳性表达与患者年龄、肿瘤大小、肿瘤部位、浸润深度、血管侵犯、淋巴结转移、远处转移及TNM分期有关。在I、II和III期，Ezrin高表达患者的5年生存率显著低于低表达患者。在IV期，Ezrin表达与5年生存率无关。多因素分析提示浸润深度、淋巴结转移、TNM分期、Ezrin表达上调是影响乳腺癌预后的独立因素。Ezrin在胃癌中的表达与淋巴结转移、远处转移及预后不良密切相关。Ezrin蛋白可能是预测肿瘤进展和预后的有用指标。
To investigat the clinical significance of Ezrin in the development and progression of gastric cancer. Immunohistochemistry was employed to analyze Ezrin expression in 436 clinicopathologically characterized gastric cancer cases. Ezrin protein levels were up-regulated in gastric cancer lesions compared with adjacent noncancerous tissues. Positive expression of Ezrin correlated with age, size of tumor, location of tumor, depth of invasion, vessel invasion, lymph node and distant metastasis and TNM stage. In stages I, II and III, the 5 year survival rate of patients with a high expression of Ezrin was significantly lower than those in patients with low expression. In stage IV, Ezrin expression did not correlate with the 5 year survival rate. Further multivariate analysis suggested that the depth of invasion, lymph node and distant metastasis, TNM stage, and up-regulation of Ezrin were independent prognostic indicators for the disease. Expression of Ezrin in gastric cancer is significantly associated with lymph node and distant metastasis, and poor prognosis. Ezrin protein could be useful markers to predict tumor progression and prognosis.