The prognostic significance of serum lactate dehydrogenase-to-albumin ratio in colorectal cancer
The prognostic significance of serum lactate dehydrogenase-to-albumin ratio in colorectal cancer
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DOI：
10.4174/astr.2020.99.3.161
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发表时间：
2020-09-01
影响因子：
1.4
通讯作者：
Akkoc, Hasan
中科院分区：
文献类型：
--
作者：
Aday, Ulas;Boyuk, Abdullah;Akkoc, Hasan
目的：我们的研究的目的是初步探讨LDH-白蛋白的比例在结直肠癌（CRC）患者接受根治性切除术的预后作用。方法：回顾性研究包括295例CRC患者接受根治性切除术。根据时间依赖性受试者工作特征（ROC）分析，治疗前LDH与白蛋白比值的最佳截止值为52.7。考克斯回归单变量和多变量分析被用来分析无病生存期（DFS）和总生存期（OS）的预后因素。结果：295名参与者包括117名女性（39.7%），总平均年龄为55.8 ± 14.1岁。中位随访期为31.8 ± 21个月（范围：6-78个月），53例患者（18.0%）在随访期间死于癌症。LDH/白蛋白比值= 52.7（n = 143）的患者的5年DFS和OS率分别为65.4%和68.5%。Kaplan-Meier曲线显示LDH/白蛋白比值>= 52.7与DFS和OS显著相关（分别为P = 0.003和P < 0.001）。多因素分析显示，LDH/白蛋白比值是大肠癌可切除的独立预测因子（优势比，2.104; 95%可信区间，1.112-3.982; P = 0.022）。LDH与白蛋白比值是临床实践中作为预后生物标志物的候选者。
Purpose: The purpose of our study was initially to explore the prognostic role of LDH-to-albumin ratio in patients with colorectal carcinoma (CRC) undergoing curative resection.Methods: The retrospective study included 295 CRC patients that underwent curative resection. According to time-dependent receiver operating characteristics (ROC) analysis, the optimal cutoff value for pretreatment LDH-to-albumin ratio was 52.7. Cox regression univariate and multivariate analyses were utilized to analyze the prognostic factors for disease-free survival (DFS) and overall survival (OS).Results: The 295 participants included 117 women (39.7%) and had an overall mean age of 55.8 +/- 14.1 years. The median follow-up period was 31.8 +/- 21 months (range, 6-78 months) and 53 patients (18.0%) died from cancer during the follow-up period. The 5-year DFS and OS rates were 65.4% and 68.5% in patients with LDH-to-albumin ratio = 52.7 (n = 143), respectively. Kaplan-Meier curves showed that LDH-to-albumin ratio >= 52.7 was significantly associated with worse DFS and OS (P = 0.003 and P < 0.001, respectively). Multivariate analyses revealed that LDH-to-albumin ratio was an independent predictor of resectable CRC (odds ratio, 2.104; 95% confidence interval, 1.112-3.982; P = 0.022).Conclusion: Our study revealed that high pretreatment LDH-to-albumin ratio level was an unfavorable prognosticator in patients with CRC undergoing curative resection. LDH-to-albumin ratio is a candidate to be a prognostic biomarker in clinical practice.