Imperfect crowding adaptation of mammalian cells towards osmotic stress and its modulation by osmolytes
Imperfect crowding adaptation of mammalian cells towards osmotic stress and its modulation by osmolytes
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DOI：
10.1039/c7mb00432j
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发表时间：
2017-11-01
影响因子：
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通讯作者：
Ebbinghaus, Simon
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文献类型：
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作者：
Gnutt, David;Brylski, Oliver;Ebbinghaus, Simon
细胞外环境的变化可以影响细胞的拥挤。为了防止有害影响，细胞使用适应机制来对这些条件做出反应。使用荧光拥挤传感器，我们表明，渗透胁迫的初始反应是快速的，但不完美的，而缓慢的反应，使细胞更耐受压力，特别是在存在渗透压。
Changes of the extracellular milieu could affect cellular crowding. To prevent detrimental effects, cells use adaptation mechanisms to react to such conditions. Using fluorescent crowding sensors, we show that the initial response to osmotic stress is fast but imperfect, while the slow response renders cells more tolerant to stress, particularly in the presence of osmolytes.