Fitness of Children With Standard-risk Acute Lymphoblastic Leukemia During Maintenance Therapy Response to a Home-based Exercise and Nutrition Program
Fitness of Children With Standard-risk Acute Lymphoblastic Leukemia During Maintenance Therapy Response to a Home-based Exercise and Nutrition Program
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DOI：
10.1097/mph.0b013e3181978fd4
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发表时间：
2009-04-01
影响因子：
1.2
通讯作者：
Bruggers, Carol S.
中科院分区：
文献类型：
--
作者：
Moyer-Mileur, Laurie J.;Ransdell, Lynda;Bruggers, Carol S.
背景：针对癌症治疗及其副作用（尤其是皮质类固醇）而改变的营养摄入量和运动减少，可能是儿童急性淋巴细胞白血病 (ALL) 幸存者体重增加和体能差异的关键因素。 目的：评估 (1) 维持治疗期间家庭营养和运动干预计划对 ALL 儿童心血管健康、力量和灵活性的影响，以及 (2) 在本研究中实施和评估家庭运动和营养计划的可行性设计：4 至 10 岁患有标准风险 ALL 的儿童在开始维持治疗时被随机分配到为期 12 个月的家庭运动和营养计划（n = 6·3 名男性/3 名女性）或对照组（n = 7、4 名男性/3 名女性）组。在基线以及研究的 6 个月和 12 个月时对人体测量学、饮食摄入量、体力活动和体能进行评估。结果：尽管两个受试者组在 0、6 和 12 个月时的年龄、体型和营养摄入量相似，但运动和营养计划儿童在 6 至 12 个月之间的体力活动和心血管健康方面比对照组儿童有更大的改善。结论：这些结果表明，维持治疗期间的家庭运动干预鼓励更多的体力活动并改善心血管健康。患有标准风险 ALL 的儿童。有必要对更多的 ALL 儿童进行进一步调查。
Background: Altered nutrient intake and decreased exercise in response to cancer therapies and their side effects, particularly corticosteroids, may be key factors in the increased body weight and differences in physical fitness reported in survivors of childhood acute lymphoblastic leukemia (ALL).Purpose: To assess (1) the effect of a home-based nutrition and exercise intervention program oil cardiovascular fitness, strength, and flexibility in children with ALL during maintenance therapy and (2) the feasibility of conducting and evaluating a home-based exercise and nutrition program in this patient population.Design: Children ages 4 to 10 years with standard-risk ALL were randomized when starting maintenance therapy to a 12-month home-based exercise and nutrition program (n = 6 3 males/3 females) or control (n = 7, 4 males/3 females) group. Assessment of anthropometrics, dietary intake, physical activity, and fitness was performed at baseline and 6 and 12 months of study.Results: Although age, body size, and nutrient intakes were similar between both subject groups at 0, 6, and 12 months, exercise and nutrition program children had greater improvement in physical activity and cardiovascular fitness between 6 and 12 months than control children.Conclusions: These results Suggest that a home-based exercise intervention during maintenance therapy encouraged greater physical activity and improved cardiovascular fitness in children with standard-risk ALL. Further investigation involving larger populations of children with ALL is warranted.