Common polymorphism in the oxytocin receptor gene (OXTR) is associated with human social recognition skills
Common polymorphism in the oxytocin receptor gene (OXTR) is associated with human social recognition skills
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DOI：
10.1073/pnas.1302985111
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发表时间：
2014-02-04
影响因子：
11.1
通讯作者：
Young, Larry J.
中科院分区：
文献类型：
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作者：
Skuse, David H.;Lori, Adriana;Young, Larry J.
神经肽催产素和加压素是进化上保守的社会感知和行为的调节剂。有证据表明，它们在啮齿类、灵长类和人类的社会识别技能的发展中起着至关重要的作用。我们研究了编码催产素和加压素1a受体的基因的常见多态性是否影响面孔的社会记忆。我们的样本包括来自英国和芬兰的198个家庭，其中一个孩子被诊断为高功能自闭症。先前的研究表明，自闭症的特征是社会感知受损，这种受损会延伸到自闭症患者的一级亲属，这意味着遗传风险。面部识别记忆、面部情绪辨别和注视方向检测的评估按年龄（7-60岁）和性别标准化。催产素受体（rs 237887）中的一个常见SNP与多重比较校正后的先证者、父母和兄弟姐妹的识别记忆密切相关。无论其诊断状态如何，祖先A等位基因的纯合子的损伤范围为-0.6至-1.15 SD评分。我们的研究结果表明，催产素系统在社会识别中的关键作用通过进化跨越了感知边界，从啮齿动物的嗅觉到人类的视觉记忆。
The neuropeptides oxytocin and vasopressin are evolutionarily conserved regulators of social perception and behavior. Evidence is building that they are critically involved in the development of social recognition skills within rodent species, primates, and humans. We investigated whether common polymorphisms in the genes encoding the oxytocin and vasopressin 1a receptors influence social memory for faces. Our sample comprised 198 families, from the United Kingdom and Finland, in whom a single child had been diagnosed with high-functioning autism. Previous research has shown that impaired social perception, characteristic of autism, extends to the first-degree relatives of autistic individuals, implying heritable risk. Assessments of face recognition memory, discrimination of facial emotions, and direction of gaze detection were standardized for age (7-60 y) and sex. A common SNP in the oxytocin receptor (rs237887) was strongly associated with recognition memory in combined probands, parents, and siblings after correction for multiple comparisons. Homozygotes for the ancestral A allele had impairments in the range -0.6 to -1.15 SD scores, irrespective of their diagnostic status. Our findings imply that a critical role for the oxytocin system in social recognition has been conserved across perceptual boundaries through evolution, from olfaction in rodents to visual memory in humans.