Depressive symptoms and increased risk of stroke mortality over a 29-year period
Depressive symptoms and increased risk of stroke mortality over a 29-year period
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DOI：
10.1001/archinte.158.10.1133
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发表时间：
1998-05-25
影响因子：
--
通讯作者：
Kaplan, GA
中科院分区：
文献类型：
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作者：
Everson, SA;Roberts, RE;Kaplan, GA
背景：多项证据表明抑郁症与心血管疾病终点有重要关系。然而，人们对抑郁症在中风死亡率中的作用知之甚少。 方法：本研究通过对来自加利福尼亚州阿拉米达县的 6676 名最初无中风成年人（45.8% 男性；79.1% 白人；基线平均年龄 43.4 岁）的社区样本中与健康和死亡率相关的行为、社会和心理因素进行前瞻性研究，探讨了抑郁症状与中风死亡率之间的关联。抑郁症状通过 18 项人类实验室抑郁量表进行评估。在控制年龄、性别、种族和其他混杂因素后，使用 Cox 比例风险回归模型评估抑郁症状的影响。结果：在 29 年的随访期间，共有 169 例中风死亡。调整年龄、性别和种族后，基线时报告 5 种或更多抑郁症状与中风死亡风险增加相关（风险比，1.66；95% 置信区间，1.16-2.39；P
Background: Several lines of evidence indicate that depression is importantly associated with cardiovascular disease end points. However, little is known about the role of depression in stroke mortality.Methods: This study examined the association between depressive symptoms and stroke mortality in a prospective study of behavioral, social, and psychological factors related to health and mortality in a community sample of 6676 initially stroke-free adults (45.8% male; 79.1% white; mean age at baseline, 43.4 years) from Alameda County, California. Depressive symptoms were assessed by the 18-item Human Population Laboratory Depression Scale. Cox proportional hazards regression models were used to evaluate the impact of depressive symptoms after controlling for age, sex, race, and other confounders.Results: A total of 169 stroke deaths occurred during 29 years of follow-up. Reporting 5 or more depressive symptoms at baseline was associated with increased risk of stroke mortality, after adjusting for age, sex, and race (hazard ratio, 1.66; 95% confidence interval, 1.16-2.39; P