Total Mercury Content in Hair and Neurologic Signs Historic Data From Minamata
Total Mercury Content in Hair and Neurologic Signs Historic Data From Minamata
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DOI：
10.1097/ede.0b013e318190e73f
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发表时间：
2009-03-01
期刊：
影响因子：
5.4
通讯作者：
Harada, Masazumi
中科院分区：
文献类型：
--
作者：
Yorifuji, Takashi;Tsuda, Toshihide;Harada, Masazumi
背景：日本（水俣和新泻）和伊拉克发生了大规模的甲基汞中毒事件。世卫组织目前的成人接触阈值（头发水平：50微克/克）是基于新泻的证据，其中仅包括急性和严重病例。方法：20世纪50年代，水俣附近的一家工厂排放甲基汞污染了白居伊海。1960年，熊本县卫生研究所的研究人员对白居伊海沿岸1694名居民的头发汞含量进行了测量。另外，1971年，熊本大学的研究人员在白井海沿岸的水俣和五所之浦地区以及有明地区（参考）进行了一项以人群为基础的研究，以检查神经系统症状。我们确定了120名居民从暴露的地区谁被列入这两个数据集，再加上730名居民的有明（未暴露的地区）谁也检查了神经signs.Results：头发汞水平与口周感觉损失的剂量-反应关系。与最低暴露类别（0-10 μ g/g）相比，口周感觉丧失的校正患病率比值比和95%置信区间分别为4.5（0.5-44）、9.1（1.0-83）和10（0.9-110），剂量类别>10 - 20、>20 - 50和>50 μ g/g。所有的神经系统症状的患病率高于在Ariake.Conclusions：神经系统症状的患病率增加，特别是口周感觉丧失，发现居民头发汞含量低于50微克/克。
Background: Large-scale methylmercury poisonings have occurred in Japan (Minamata and Niigata) and in Iraq. The current WHO threshold for adult exposure (hair level: 50 mu g/g) was based on evidence from Niigata, which included only acute and severe cases. That study leaves open the possibility of more subtle effects at lower exposure levels.Methods: The Shiranui sea had been contaminated in the 1950s by the discharge of methylmercury from a factory near Minamata.In 1960, the hair mercury content of 1694 residents living on the coastline of the Shiranui sea was measured by researchers from the Kumamoto Prefecture Institute for Health Research. Independently, in 1971, a population-based study to examine neurologic signs was conducted in the Minamata and Goshonoura areas, on the coastline of the Shiranui Sea, and the Ariake area (reference), by researchers at Kumamoto University. We identified 120 residents from exposed areas who were included in both datasets, plus 730 residents of Ariake (an unexposed area) who were also examined for neurologic signs.Results: Hair mercury levels were associated with perioral sensory loss in a dose-response relationship. The adjusted prevalence odds ratios and 95% confidence intervals for perioral sensory loss, compared with the lowest exposure category (0-10 mu g/g), were 4.5 (0.5-44), 9.1 (1.0-83), and 10 (0.9-110), for the dose categories >10 to 20, >20 to 50, and >50 mu g/g, respectively. The prevalence of all neurologic signs was higher in the exposure area than in Ariake.Conclusions: An increased prevalence of neurologic signs, especially perioral sensory loss, was found among residents with hair mercury content below 50 mu g/g.