Dietary antioxidants, supplements, and risk of epithelial ovarian cancer
Dietary antioxidants, supplements, and risk of epithelial ovarian cancer
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DOI：
10.1207/s15327914nc402_3
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发表时间：
2001-01-01
影响因子：
2.9
通讯作者：
Harlap, S
中科院分区：
文献类型：
--
作者：
Fleischauer, AT;Olson, SH;Harlap, S
一些关于饮食和血清抗氧化微量营养素（维生素A、C和E以及β-胡萝卜素）的研究表明，较高的水平可能对卵巢癌有保护作用。这些都没有检查过补充剂。我们使用食物频率问卷和补充剂的附加问题研究了168例组织学证实的上皮性卵巢癌病例，159例社区对照和92例医院对照。饮食或补充剂中的抗氧化剂消耗量以毫克或国际单位/天计算。在仅使用社区对照的多变量分析中，从补充剂中摄入维生素C和E的最高水平具有保护作用：比值比（OR）= 0.40 [95%置信区间（CI）= 0.21 - 0.78]和OR = 0.33（95% CI = 0.18 - 0.60）。从饮食中摄入抗氧化剂与风险无关。在结合饮食和补充剂中的抗氧化剂摄入量的分析中，维生素C（> 363 mg/天）和E（> 75 mg/天）与风险降低相关：OR = 0.45（95% CI = 0.22 - 0.91）和OR = 0.44（95% CI = 0.21 - 0.94）。在结合两个对照组的分析中，结果相似，向零值有一些衰减。与保护作用相关的维生素C和E水平远高于目前美国推荐的膳食允许量。这些发现支持了补充剂中的抗氧化维生素C和E与降低卵巢癌风险有关的假设。
Several studies of dietary and serum antioxidant micronutrients (vitamins A, C, and E and beta-carotene) suggest that higher levels may be protective for ovarian cancer. None of these has examined supplements. We used a food frequency questionnaire and additional questions on supplem- ents to study 168 histologically confirmed epithelial ovarian cancer cases, 159 community controls, and 92 hospital-based controls. Antioxidant consumption from diet or supplements was calculated in milligrams or international units per day. In multivariate analyses using only community controls, the highest levels of intake of vitamins C and E from supplements were protective: odds ratio (OR) = 0.40 [95% confidence interval (CI) = 0.21-0.78] and OR = 0.33 (95% CI = 0.18-0.60), respectively. Consumption of antioxidants from diet was unrelated to risk. In analyses combining antioxidant intake from diet and supplements, vitamins C (>363 mg/day) and E (>75 mg/day) were associated with reduced risks: OR = 0.45 (95% CI = 0.22-0.91) and OR = 0.44 (95% CI = 0.21-0.94), respectively. Results were similar, with some attenuation toward the null, in analyses combining both control groups. The levels of vitamins C and E associated with the protective effect were well above the current US Recommended Dietary Allowances. These findings support the hypothesis that antioxidant vitamins C and E from supplements are related to a reduced risk of ovarian cancer.