Repeated maternal separation of preweanling rats attenuates behavioral response to primary and conditioned incentives in adulthood
Repeated maternal separation of preweanling rats attenuates behavioral response to primary and conditioned incentives in adulthood
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DOI：
10.1016/0031-9384(95)02069-1
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发表时间：
1996-01-01
影响因子：
2.9
通讯作者：
Robbins, Trevor W.
中科院分区：
文献类型：
--
作者：
Matthews, Keith;Wilkinson, Lawrence S.;Robbins, Trevor W.
早期的社会经验对大鼠的广泛行为和神经化学相关有深远的影响。在新生早期，反复将幼鼠从母体中分离出来，会引起神经内分泌和生理状态的急性扰动。反复分离的慢性后遗症还没有像急性反应那样被广泛研究。已知，在发育的后期阶段，即断奶后的隔离饲养阶段，改变的社会经验会导致成熟阶段对奖赏和与奖赏相关的刺激的行为反应发生持久的变化。我们评估了反复早期母体分离对成年大鼠对初级和条件性刺激的反应的影响。分离的动物表现出体重增加，对新环境的运动反应迟钝，对消极和积极对比效应的反应迟钝。雌性分离的动物，而不是雄性，表现出对食物呈现的条件性预期运动反应的获得的显著减弱。这些数据涉及腹侧纹状体多巴胺系统参与奖赏机制的推测，以及早期母体分离作为抑郁症动物模型的潜在用途。
Early social experience has profound effects on a wide spectrum of behaviors and neurochemical correlates in the rat. Repeated separation of rat pups from their dam during the early neonatal period causes acute perturbation of neuroendocrine and physiological status. The chronic sequelae of repeated separations have not been studied as extensively as the acute responses. Altered social experience at a later developmental stage, postweaning isolation rearing, is known to induce enduring changes in the behavioral responses to reward and reward-related stimuli in maturity. We have evaluated the influence of repeated early maternal separation on the responses to both primary and conditioned incentives in mature rats. Separated animals showed enhanced weight gain, a blunted locomotor response to a novel environment and a blunting of the response to both negative and positive contrast effects. Female separated animals, but not males, exhibited a profound attenuation of the acquisition of a conditioned anticipatory locomotor response to the presentation of food. These data are discussed with respect to the putative involvement of ventral striatal dopamine systems in reward mechanisms and the potential utility of early maternal separation as an animal model of depression.