Medial septal lesions mimic effects of both selective dorsal and ventral hippocampal lesions
Medial septal lesions mimic effects of both selective dorsal and ventral hippocampal lesions
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DOI：
10.1037/0735-7044.118.5.1033
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发表时间：
2004-10-01
影响因子：
1.9
通讯作者：
Rawlins, JNP
中科院分区：
文献类型：
--
作者：
Bannerman, DM;Matthews, P;Rawlins, JNP
电解内侧隔（MS）病变，耗尽乙酰胆碱酯酶染色在背侧和腹侧海马，产生了一系列的行为，结合方面的选择性背侧和腹侧海马病变的影响。MS病变损害空间工作记忆的T迷宫，因此类似的背海马病变的影响。此外，多发性硬化症病变减少了焦虑，在连续的小巷（高架十字迷宫的修改形式），社会交往，hyponeophagia测试。MS病变也减少了休克后冻结。这些影响更接近腹侧海马病变。因此，电解MS病变的影响来自于背侧和腹侧海马区的联合传入神经阻滞，表明先前报道的细胞毒性背侧海马病变的影响不太可能是由于穿过隔极的通道纤维脱髓鞘所致。
Electrolytic medial septal (MS) lesions, which depleted acetylcholinesterase staining in both dorsal and ventral hippocampus, produced a constellation of behaviors, combining aspects of both selective dorsal and ventral hippocampal lesion effects. MS lesions impaired spatial working memory on the T maze, thus resembling the effects of dorsal hippocampal lesions. In addition, MS lesions reduced anxiety during successive alleys (a modified form of the elevated plus-maze), social interaction, and hyponeophagia tests. MS lesions also reduced postshock freezing. These effects more closely resemble those of ventral hippocampal lesions. Therefore, the effects of electrolytic MS lesions derive from the resulting combined deafferentation of dorsal and ventral hippocampal regions, suggesting that previously reported effects of cytotoxic dorsal hippocampal lesions are unlikely to be due to a demyelination of fibers of passage coursing through the septal pole.